What Sustains Life?
Consilient Mechanisms for Protein-Based Machines and Materials
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Biology’s Unique Phase Transition Drives Cell Function
Systematic designs, physical characterizations and data analyses of elastic-contractile model proteins have given rise to a series of physical concepts associated with phase transitions of hydrophobic associat...
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Deciphering engineering principles for the design of protein-based nanomachines
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Article
Development of Elastic Protein-based Polymers as Materials for Acoustic Absorption
Elastic protein-based polymers comprised of repeating pentapeptide sequences, (GXGXP)n, exhibit mechanical resonances that have been observed to date with frequency maxima near 5 MHz and 3 kHz. Because the 3 kHz ...
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Five axioms for protein engineering: Keys for understanding protein structure/function?
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Chapter
ΔTt-Mechanism in the Design of Self-Assembling Structures
Protein-based polymers can be designed in which self-assembly occurs as the temperature is raised above the onset temperature, Tt, of an inverse temperature transition for hydrophobic folding and assembly. Instea...
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Hyperexpression of a Synthetic Protein-Based Polymer Gene
Environmental problems require the development of biodegradable plastics of benign production that can be synthesized from renewable resources without the use of toxic and hazardous chemicals and will help in ...
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Proteins: Structure, folding and function
Living organisms evolved by develo** the capacity to convert an available form of energy into a useful form of energy; how well they thrive depends on how effectively a needed conversion is performed.
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Article
Expression of an environmentally friendly synthetic protein-based polymer gene in transgenic tobacco plants
We report the expression of a protein-based polymer (Gly-Val-Gly-Val-Pro)121, i. e., (GVGVP)121 in transgenic tobacco (Nicotiana tabacum var. Kentucky 17) plants. The plant expression vector pBI121-XZ-120mer whic...
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Conversion of Available Energy Forms into Desired Forms by a Biologically Accessible Mechanism
The energy conversions considered here are achieved by the appropriate design of polypeptides or what may also be called protein-based polymers or model proteins. As these involve biomolecular compositions der...
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Synthesis, Characterizations, and Medical Applications of Bioelastic Materials
Bioelastic materials are elastomeric polypeptides composed of repeating sequences. They are a relatively new class of polymers that may also be called elastic protein-based polymers, having their origins in re...
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Cell Adhesive Properties of Bioelastic Materials Containing Cell Attachment Sequences
The biocompatibility, conformational and inverse temperature transition properties of poly(Vall-Pro2-Gly3-Va14- Gly5), i.e., poly(VPGVG), and its 7-irradiation crosslinked matrix and the poly(VPGVG)-derived hydro...
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Bioelastic Materials as Matrices for Tissue Reconstruction
Bioelastic materials are elastomeric polypeptides whose origins are repeating peptide sequences in mammalian elastic fibers (Sandberg et al., 1985; Yeh et al., 1987; Indik et al., 1987). Physical properties of...
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The Poly(nonapeptide) of Elastin: A New Elastomeric Polypeptide Biomaterial
This paper reports the first data on a new member of the class of elastomeric polypeptide biomaterials. The new member is poly(VPGFGVGAG). The synthesis is demonstrated by carbon-13 and proton nuclear magnetic...
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Elastomeric Polypeptide Biomaterials: Structure and Free Energy Transduction
The primary, secondary, tertiary and quaternary structures are presented and discussed for elastomeric polypeptides capable of undergoing inverse temperature transitions, that is, these polypeptides fold with ...
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Article
Entropic elastic processes in protein mechanisms. II. Simple (passive) and coupled (active) development of elastic forces
The first part of this review on entropic elastic processes in protein mechanisms (Urry, 1988) demonstrated with the polypentapeptide of elastin (Val1-Pro2-Gly3-Val4-Gly5)n that elastic structure develops as the ...
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Entropic elastic processes in protein mechanisms. I. Elastic structure due to an inverse temperature transition and elasticity due to internal chain dynamics
Numerous physical characterizations clearly demonstrate that the polypentapeptide of elastin (Val1-Pro2-Gly3-Val4-Gly5)u in water undergoes an inverse temperature transition. Increase in order occurs both intermo...
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Absorption and Optical Rotation Spectra of Biological Membranes
The combination of ultraviolet absorption and circular dichroism (CD) spectroscopies provides a sensitive technique for following protein conformation and conformational changes in solution. It is reasonable t...
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Chapter
Absorption and Optical Rotation Spectra of Biological Membranes
The combination of ultraviolet absorption and circular dichroism (CD) spectroscopies provides a sensitive technique for following protein conformation and conformational changes in solution. It is reasonable t...
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Chemical basis of ion transport specificity in biological membranes
This review addresses the issues of the chemical and physical processes whereby inorganic anions and cations are selectively retained by or passed through cell membranes. The channel and carrier mechanisms of ...
