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Open AccessEssential amino acid supplements ingestion has a positive effect on executive function after moderate-intensity aerobic exercise
Aerobic exercise acutely improves cognitive function (e.g., executive function (EF); memory recognition (MR)) and increases circulating brain-derived neurotrophic factor (BDNF). In addition, branched-chain ami...
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Article
Open AccessBeiging of perivascular adipose tissue regulates its inflammation and vascular remodeling
Although inflammation plays critical roles in the development of atherosclerosis, its regulatory mechanisms remain incompletely understood. Perivascular adipose tissue (PVAT) has been reported to undergo infla...
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Article
Measuring productivity dynamics in Japan: a quantile approach
This paper presents an approach for estimating changes in firms’ productivity. We apply the quantile approach, which estimates the changes in the productivity distribution of surviving firms. Using this method...
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Open AccessPublisher Correction: Computation-guided asymmetric total syntheses of resveratrol dimers
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Open AccessComputation-guided asymmetric total syntheses of resveratrol dimers
Although computational simulation-based natural product syntheses are in their initial stages of development, this concept can potentially become an indispensable resource in the field of organic synthesis. He...
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Article
The impact of improvement in public transportation: evidence from the Tokyo metropolitan area
This study examines the effect of improvement in public transportation on population and employment distribution in the Tokyo metropolitan area. Using an instrumental variable, my analysis reveals two notewort...
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Article
Open AccessFactors associated with left ventricular reverse remodelling after percutaneous coronary intervention in patients with left ventricular systolic dysfunction
Percutaneous coronary intervention (PCI) is sometimes considered as an alternative therapeutic strategy to surgical revascularization in patients with coronary artery disease (CAD) and reduced left ventricular...
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Article
Open AccessOmega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
Some clinical trials showed that omega-3 fatty acid (FA) reduced cardiovascular events, but it remains unknown whether omega-3 FA supplementation changes the composition of FAs and their metabolites in the hea...
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Open AccessLate presentation of arrhythmogenic right ventricular cardiomyopathy in an octogenarian associated with a pathogenic variant in the plakophilin 2 gene: a case report
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited myocardial disease characterized by fibrofatty replacement and ventricular arrhythmias. ARVC is believed to be a disease of the young, wit...
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Article
Open AccessDynamic laminar rerouting of inter-areal mnemonic signal by cognitive operations in primate temporal cortex
Execution of cognitive functions is orchestrated by a brain-wide network comprising multiple regions. However, it remains elusive whether the cortical laminar pattern of inter-areal interactions exhibits dynam...
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In-hospital outcomes of acute myocardial infarction with cardiogenic shock caused by right coronary artery occlusion vs. left coronary artery occlusion
In-hospital outcomes of acute myocardial infarction (AMI) with cardiogenic shock (CS) were still not satisfactory even in the primary percutaneous coronary intervention (PCI) era. The aim of this study was to ...
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Article
Open AccessSuccessful bridge to recovery in fulminant myocarditis using a biventricular assist device: a case report
Fulminant myocarditis is a life-threatening disease, and myocardial damage expands the right ventricle as well as the left ventricle in some cases. There is a mortality rate of over 40% in patients with fulmin...
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Open AccessLow plasma tryptophan is associated with olfactory function in healthy elderly community dwellers in Japan
Decreased circulating tryptophan (Trp) levels are frequently observed in elderly patients with neurodegenerative disease including Alzheimer’s disease. Trp may serve as a potential biomarker for monitoring dis...
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Article
Comparison of mid-term clinical outcomes between on-label and off-label use of rotational atherectomy
While rotational atherectomy (RA) is used for complex lesions in percutaneous coronary intervention, there are several contraindications such as unprotected left main stenosis or left ventricular dysfunction. ...
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Article
Open AccessMammalian autophagy is essential for hepatic and renal ketogenesis during starvation
Autophagy is an intracellular degradation system activated, across species, by starvation. Although accumulating evidence has shown that mammalian autophagy is involved in pathogenesis of several modern diseas...
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Molecular mechanism of antidiabetic zinc–allixin complexes: regulations of glucose utilization and lipid metabolism
We previously reported new zinc complexes of allixin [bis(allixinato)zinc] and its derivative bis(thioallixin-N-methyl)zinc that demonstrated excellent antidiabetic activity in type 2 diabetic mellitus KKAy mice....
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Article
Action mechanism of bis(allixinato)oxovanadium(IV) as a novel potent insulin-mimetic complex: regulation of GLUT4 translocation and FoxO1 transcription factor
Bis(allixinato)oxovanadium(IV), VO(alx)2 (alx is 3-hydroxy-5-methoxy-6-methyl-2-pentyl-4-pyrone), has been reported to act as an antidiabetic agent in streptozotocin-induced type-1-like and obesity-linked KKAy ty...
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Article
Metallokinetic characteristics of antidiabetic bis(allixinato)oxovanadium(IV)-related complexes in the blood of rat
The antidiabetic effect of vanadium is a widely accepted phenomenon; some oxovanadium(IV) complexes have been found to normalize high blood glucose levels in both type 1 and type 2 diabetic animals. In light o...
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Article
Isolation of a bacterium that degrades urethane compounds and characterization of its urethane hydrolase
A bacterium which degrades urethane compounds was isolated and identified as Rhodococcus equi strain TB-60. Strain TB-60 degraded toluene-2,4-dicarbamic acid dibutyl ester (TDCB) and accumulated toluene diamine a...
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The Pharmacology of the Insulinomimetic Effect of Zinc Complexes
In develo** new insulinomimetic zinc(II) complexes with different coordination structures and with a blood glucose-lowering effect to treat type 2 diabetic animals, we found a potent bis(maltolato)zinc(ll) c...