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Article
Open AccessLow-carbohydrate diets containing plant-derived fat but not animal-derived fat ameliorate heart failure
Cardiovascular disease (CVD) is a global health burden in the world. Although low-carbohydrate diets (LCDs) have beneficial effects on CVD risk, their preventive effects remain elusive. We investigated whether...
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Article
Open AccessSpatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction
The underlying mechanisms of ventricular remodeling after myocardial infarction (MI) remain largely unknown. In this study, we performed an integrative analysis of spatial transcriptomics and single-nucleus RN...
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Article
Open AccessCardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis
Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart failure, but it remains elusive whether there is a common pathway to induce both events. Through single-cell RNA-seq,...
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Article
Open AccessAuthor Correction: CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor
Most seven transmembrane receptors (7TMRs) are G protein-coupled receptors; however, some 7TMRs evoke intracellular signals through β-arrestin as a biased receptor. As several β-arrestin-biased agonists have b...
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Article
Open AccessOmega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
Some clinical trials showed that omega-3 fatty acid (FA) reduced cardiovascular events, but it remains unknown whether omega-3 FA supplementation changes the composition of FAs and their metabolites in the hea...
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Article
Open AccessCardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure
Pathophysiological roles of cardiac dopamine system remain unknown. Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in triggering heart failure-associated ventricular arrhy...
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Article
Open AccessCardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte remodeling and clarify distinct...
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Article
Open AccessGenetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling
Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) are genetically and phenotypically heterogeneous. Cardiac function is improved after treatment in some cardiomyopathy patients, but little is ...
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Article
Open AccessIdentification of MYLK3 mutations in familial dilated cardiomyopathy
Dilated cardiomyopathy (DCM) is a primary cause of heart failure, life-threatening arrhythmias, and cardiac death. Pathogenic mutations have been identified at the loci of more than 50 genes in approximately 5...
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Article
Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells
Phase I clinical trials applying autologous progenitor cells to treat heart failure have yielded promising results; however, improvement in function is modest, indicating a need to enhance cardiac stem cell re...
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Article
Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth
Ability of the heart to undergo pathological or physiological hypertrophy upon increased wall stress is critical for long-term compensatory function in response to increased workload demand. While substantial ...
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Article
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
Cardiac enlargement, or hypertrophy, is a physiological response to increased workload and helps to maintain cardiac function. If the condition is prolonged, however, it can develop into heart failure. New ins...
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Article
The Gene Expression Profiling of Concentric and Eccentric Cardiac Hypertrophy
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Article
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
Granulocyte colony-stimulating factor (G-CSF) was reported to induce myocardial regeneration by promoting mobilization of bone marrow stem cells to the injured heart after myocardial infarction, but the precis...
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Article
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress through an angiotensin-II-independent m...
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Chapter
Ca2+—Dependent Signaling Pathways Through Calcineurin and Ca2+ Calmodulin—Dependent Protein Kinase in Development of Cardiac Hypertrophy
Cardiac hypertrophy is induced by a variety of cardiovascular diseases such as hypertension, valvular diseases, myocardial infarction, cardiomyopathy, and endocrine disorders. Although cardiac hypertrophy may ...
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Chapter
Age-Related Anisotropic Changes in Cardiocyte Connections in Spontaneously Hypertensive Rats
An individual cardiocyte connects to adjacent cells at the ends and the sides of the cell in various ways. In this scanning electron microscopic (SEM) study, we compared the number and the mode of cardiocyte c...
