5 Result(s)
within
Toshiyuki Hirabayashi
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Article
Open AccessMultiscale chemogenetic dissection of fronto-temporal top-down regulation for object memory in primates
Visual object memory is a fundamental element of various cognitive abilities, and the underlying neural mechanisms have been extensively examined especially in the anterior temporal cortex of primates. However...
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Article
Open AccessChemogenetic attenuation of cortical seizures in nonhuman primates
Epilepsy is a disorder in which abnormal neuronal hyperexcitation causes several types of seizures. Because pharmacological and surgical treatments occasionally interfere with normal brain function, a more foc...
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Article
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys
The chemogenetic technology designer receptors exclusively activated by designer drugs (DREADDs) afford remotely reversible control of cellular signaling, neuronal activity and behavior. Although the combinati...
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Article
Open AccessDynamic laminar rerouting of inter-areal mnemonic signal by cognitive operations in primate temporal cortex
Execution of cognitive functions is orchestrated by a brain-wide network comprising multiple regions. However, it remains elusive whether the cortical laminar pattern of inter-areal interactions exhibits dynam...
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Article
Open AccessPET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
The rostromedial caudate (rmCD) of primates is thought to contribute to reward value processing, but a causal relationship has not been established. Here we use an inhibitory DREADD (Designer Receptor Exclusiv...
