8 Result(s)
within
Life Sciences
Yi-hui **
Article
-
Article
Open AccessControl of false discoveries in grouped hypothesis testing for eQTL data
Expression quantitative trait locus (eQTL) analysis aims to detect the genetic variants that influence the expression of one or more genes. Gene-level eQTL testing forms a natural grouped-hypothesis testing st...
-
Article
Open AccessC3NA: correlation and consensus-based cross-taxonomy network analysis for compositional microbial data
Studying the co-occurrence network structure of microbial samples is one of the critical approaches to understanding the perplexing and delicate relationship between the microbe, host, and diseases. It is also...
-
Article
Open AccessMiRNA-124-3p.1 sensitizes hepatocellular carcinoma cells to sorafenib by regulating FOXO3a by targeting AKT2 and SIRT1
As a multikinase inhibitor, sorafenib is commonly used to treat patients with advanced hepatocellular carcinoma (HCC), however, acquired resistance to sorafenib is a major obstacle to the effectiveness of this...
-
Article
Open AccessProtection of ZIKV infection-induced neuropathy by abrogation of acute antiviral response in human neural progenitors
It remains largely unknown how Zika virus (ZIKV) infection causes severe microcephaly in human newborns. We examined an Asian lineage ZIKV, SZ01, which similarly infected and demonstrated comparable growth arr...
-
Article
Open AccessAkt inhibitor SC66 promotes cell sensitivity to cisplatin in chemoresistant ovarian cancer cells through inhibition of COL11A1 expression
We studied Akt inhibition using SC66 in a NOD-SCID xenograft mouse model and a panel of eight ovarian cancer cell lines. Elevated phospho-Akt levels in cancerous tissue were associated with short progression-f...
-
Article
Open AccessSmad5 acts as an intracellular pH messenger and maintains bioenergetic homeostasis
Both environmental cues and intracellular bioenergetic states profoundly affect intracellular pH (pHi). How a cell responds to pHi changes to maintain bioenergetic homeostasis remains elusive. Here we show tha...
-
Article
Open AccessEmergence of differentially regulated pathways associated with the development of regional specificity in chicken skin
Regional specificity allows different skin regions to exhibit different characteristics, enabling complementary functions to make effective use of the integumentary surface. Chickens exhibit a high degree of r...
-
Article
Open AccessMsx1 and Msx2are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium
Msx1 and Msx2, which belong to the highly conserved Nk family of homeobox genes, display overlap** expression patterns and redundant functions in multiple tissues and organs during vertebrate development. Msx1 ...
