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  1. No Access

    Article

    A phase II, open-label, sequential-cohort, dose-escalation study of romiplostim in Japanese patients with chronic immune thrombocytopenic purpura

    This phase II, multicenter, open-label, sequential-cohort, dose-escalation study was designed to evaluate the safety and efficacy of romiplostim, a novel peptibody that increases platelet production, in Japane...

    Yukari Shirasugi, Kiyoshi Ando, Satoshi Hashino… in International Journal of Hematology (2009)

  2. No Access

    Article

    An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2

    Dendritic cells (DC), genetically modified to express ovalbumin by the retroviral vector GCDNsap, can elicit stronger anti-tumor immunity than those loaded with the peptides. To assess the clinical feasibility...

    Tsukasa Nabekura, Toshiro Nagasawa, Hiromitsu Nakauchi… in Cancer Immunology, Immunotherapy (2008)

  3. No Access

    Article

    L-Arginine Administration Reverses Anemia Associated with Renal Disease

    Recombinant human erythropoietin (rhEpo) has proved to be remarkably safe and effective for the treatment of anemia. Despite the use of rhEpo, concerns about its cost, the need for frequent parenteral administ...

    Takahisa Tarumoto, Shigehiko Imagawa… in International Journal of Hematology (2007)

  4. No Access

    Article

    Successful Treatment of a Patient with POEMS Syndrome by Tandem High-Dose Chemotherapy with Autologous CD34+ Purged Stem Cell Rescue

    A 36-year-old man was admitted because of numbness and muscle weakness in the lower extremities. He had gait disturbance, malaise, and body weight loss. Based on the existence of monoclonal gammopathy, the pro...

    Hiroshi Kojima, Yuna Katsuoka, Yukitaka Katsura… in International Journal of Hematology (2006)

  5. No Access

    Article

    Refinement of cytokine use in the in vitro expansion of erythroid cells

    Blood transfusion is indispensable for many clinical applications. However, the supply of transfusable material is insufficient in many countries. Human cord blood contains many hematopoietic stem and progenit...

    Ken-Ichi Miharada, Takashi Hiroyama, Kazuhiro Sudo, Toshiro Nagasawa… in Human Cell (2006)

  6. No Access

    Article

    Identification of a Chromosomal Breakpoint and Detection of a Novel Form of an MLL- AF17 Fusion Transcript in Acute Monocytic Leukemia with t(11;17)(q23;q21)

    More than 40 genes have been reported as translocation partners of the mixed lineage leukemia gene(MLL) in hematologic malignancies.AF17 was identified earlier than most otherMLL translocation partners. On the ot...

    Kazumi Suzukawa, Seiichi Shimizu, Noriko Nemoto… in International Journal of Hematology (2005)

  7. No Access

    Article

    Abstract of Poster Presentation

    Hiroshi Uchida, Tetsuo Maruyama, Jkuko Sugiura, Takashi Kajitani, Touru Arase… in Human Cell (2005)

  8. No Access

    Article

    Cytotoxic T-Cell Lymphoma Arising in Behçet Disease

    The case of a 49-year-old man with peripheral T-cell lymphoma arising in Behçet disease (BD) is reported. A diagnosis of incomplete BD was made, and the patient was treated with immunosuppressive agents for 9 ...

    Yukitaka Katsura, Kazumi Suzukawa, Hiroshi Kojima… in International Journal of Hematology (2003)

  9. No Access

    Article

    GATA Suppresses Erythropoietin Gene Expression through GATA Site in Mouse Erythropoietin Gene Promoter

    The promoter and enhancer elements of the mouse erythropoietin (mEpo) gene, which have high homology with those of the human erythropoietin (hEpo) gene, were fused withluciferase. The construct was transfected in...

    Shigehiko Imagawa, Norio Suzuki, Ken Ohmine… in International Journal of Hematology (2002)

  10. No Access

    Article

    Lupus Anticoagulant-Like Activity Observed in a Dimeric λ Protein Produced by Myeloma Cells

    We report here a lupus anticoagulant (LA)-like activity observed in a 45-year-old man with Bence-Jones protein (BJP) λ-type multiple myeloma. This patient showed no clinical symptoms of thrombosis or bleeding ...

    Atsushi Shinagawa, Hiroshi Kojima… in International Journal of Hematology (2001)

  11. No Access

    Article

    Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets

    Tec is a non-receptor type tyrosine kinase which is tyrosine phosphorylated and activated upon stimulation of hematopoietic cells with various cytokines. The role of Tec in G protein-coupled receptor- and inte...

    Yoko Hamazaki, Hiroshi Kojima, Hiroyuki Mano, Yuka Nagata, Kazuo Todokoro… in Oncogene (1998)