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  1. Article

    Open Access

    Identification of a gene set that maintains tumorigenicity of the hepatocellular carcinoma cell line Li-7

    The identification and development of therapeutic targets in cancer stem cells that lead to tumor development, recurrence, metastasis, and drug resistance is an important goal in cancer research. The hepatocel...

    Yusuke Seyama, Kazuhiro Sudo, Suguru Hirose, Yukako Hamano, Takeshi Yamada… in Human Cell (2023)

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  2. No Access

    Article

    Chemically defined cytokine-free expansion of human haematopoietic stem cells

    Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and immune systems after transplantation and can be used as a curative cell therapy for a variety of haematological dise...

    Masatoshi Sakurai, Kantaro Ishitsuka, Ryoji Ito, Adam C. Wilkinson… in Nature (2023)

  3. Article

    Author Correction: Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation

    An Amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita… in Nature (2019)

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    Article

    Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation

    Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult blood system after transplantation1, which is a curative therapy for numerous diseases including immunodeficiencies and leukaemias2....

    Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita… in Nature (2019)

  5. No Access

    Article

    Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells

    Erythroblast enucleation is thought to be largely dependent on signals mediated by other cells, such as macrophages. In an attempt to improve the in vitro production of red blood cells (RBCs) from immature hemato...

    Kenichi Miharada, Takashi Hiroyama, Kazuhiro Sudo, Toshiro Nagasawa… in Nature Biotechnology (2006)

  6. No Access

    Article

    Refinement of cytokine use in the in vitro expansion of erythroid cells

    Blood transfusion is indispensable for many clinical applications. However, the supply of transfusable material is insufficient in many countries. Human cord blood contains many hematopoietic stem and progenit...

    Ken-Ichi Miharada, Takashi Hiroyama, Kazuhiro Sudo, Toshiro Nagasawa… in Human Cell (2006)

  7. No Access

    Article

    Abstract of Poster Presentation

    Hiroshi Uchida, Tetsuo Maruyama, Jkuko Sugiura, Takashi Kajitani, Touru Arase… in Human Cell (2005)

  8. No Access

    Chapter and Conference Paper

    Isolation and Characterization of CD34-Low/Negative Mouse Hematopoietic Stem Cells

    We have previously reported that, in adult mouse bone marrow, CD34low/− c-Kit+ Sca-1+ lineage markers negative (Lin−) (CD34−KSL) cells represent hematopoietic stem cells with long-term marrow repopulating ability...

    Hiromitsu Nakauchi, Masatake Osawa, Kazuhiro Sudo, Hideo Ema in Cell Therapy (2000)