16 Result(s)
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Article
Toshiro Nagasawa
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A phase II, open-label, sequential-cohort, dose-escalation study of romiplostim in Japanese patients with chronic immune thrombocytopenic purpura
This phase II, multicenter, open-label, sequential-cohort, dose-escalation study was designed to evaluate the safety and efficacy of romiplostim, a novel peptibody that increases platelet production, in Japane...
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An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2
Dendritic cells (DC), genetically modified to express ovalbumin by the retroviral vector GCDNsap, can elicit stronger anti-tumor immunity than those loaded with the peptides. To assess the clinical feasibility...
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L-Arginine Administration Reverses Anemia Associated with Renal Disease
Recombinant human erythropoietin (rhEpo) has proved to be remarkably safe and effective for the treatment of anemia. Despite the use of rhEpo, concerns about its cost, the need for frequent parenteral administ...
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Quinupristin/dalfopristin and voriconazole controlled Staphylococcus epidermidis pneumonia and chronic necrotizing aspergillosis in a patient with severe lung degradation consequent to multiple treatments for Hodgkin's lymphoma
We report here a 34-year-old woman with complicated severe opportunistic pulmonary infection, who was treated with the newly developed antibiotics quinupristin/dalfopristin (QPR/DPR) and voriconazole. She had ...
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Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cells
Erythroblast enucleation is thought to be largely dependent on signals mediated by other cells, such as macrophages. In an attempt to improve the in vitro production of red blood cells (RBCs) from immature hemato...
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Successful Treatment of a Patient with POEMS Syndrome by Tandem High-Dose Chemotherapy with Autologous CD34+ Purged Stem Cell Rescue
A 36-year-old man was admitted because of numbness and muscle weakness in the lower extremities. He had gait disturbance, malaise, and body weight loss. Based on the existence of monoclonal gammopathy, the pro...
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Exposure of medical staff to Strongyloides stercolaris from a patient with disseminated strongyloidiasis
We examined whether medical staff were infected with Strongyloides stercolaris through exposure to the body substances of a patient with disseminated strongyloidiasis. The patient excreted a large number of S. st...
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Refinement of cytokine use in the in vitro expansion of erythroid cells
Blood transfusion is indispensable for many clinical applications. However, the supply of transfusable material is insufficient in many countries. Human cord blood contains many hematopoietic stem and progenit...
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Identification of a Chromosomal Breakpoint and Detection of a Novel Form of an MLL- AF17 Fusion Transcript in Acute Monocytic Leukemia with t(11;17)(q23;q21)
More than 40 genes have been reported as translocation partners of the mixed lineage leukemia gene(MLL) in hematologic malignancies.AF17 was identified earlier than most otherMLL translocation partners. On the ot...
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Abstract of Poster Presentation
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Suppression of erythropoietin gene expression by cadmium depends on inhibition of HIF-1, not stimulation of GATA-2
Long-term exposure of rats to cadmium (Cd) resulted in a marked suppression of erythropoietin (Epo) mRNA expression in the kidneys and the development of severe anemia. A recent report revealed that Cd inhibit...
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Cytotoxic T-Cell Lymphoma Arising in Behçet Disease
The case of a 49-year-old man with peripheral T-cell lymphoma arising in Behçet disease (BD) is reported. A diagnosis of incomplete BD was made, and the patient was treated with immunosuppressive agents for 9 ...
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GATA Suppresses Erythropoietin Gene Expression through GATA Site in Mouse Erythropoietin Gene Promoter
The promoter and enhancer elements of the mouse erythropoietin (mEpo) gene, which have high homology with those of the human erythropoietin (hEpo) gene, were fused withluciferase. The construct was transfected in...
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Lupus Anticoagulant-Like Activity Observed in a Dimeric λ Protein Produced by Myeloma Cells
We report here a lupus anticoagulant (LA)-like activity observed in a 45-year-old man with Bence-Jones protein (BJP) λ-type multiple myeloma. This patient showed no clinical symptoms of thrombosis or bleeding ...
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Characterization of a human cell line derived from liposarcoma tissue: Is the beta subunit of prolyl 4-hydroxylase specific for a fibroblastic phenotype in culture cells?
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Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets
Tec is a non-receptor type tyrosine kinase which is tyrosine phosphorylated and activated upon stimulation of hematopoietic cells with various cytokines. The role of Tec in G protein-coupled receptor- and inte...
