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Shared and unique transcriptomic signatures of antidepressant and probiotics action in the mammalian brain
Understanding the shared and divergent mechanisms across antidepressant (AD) classes and probiotics is critical for improving treatment for mood disorders. Here we examine the transcriptomic effects of bupropi...
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Article
Open AccessIntegrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling
Depression and anxiety are major global health burdens. Although SSRIs targeting the serotonergic system are prescribed over 200 million times annually, they have variable therapeutic efficacy and side effects...
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Article
Open AccessGenomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress
The multifactorial etiology of stress-related disorders necessitates a constant interrogation of the molecular convergences in preclinical models of stress that use disparate paradigms as stressors spanning fr...
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Article
Brain-Derived Neurotrophic Factor in the Nucleus Accumbens Mediates Individual Differences in Behavioral Responses to a Natural, Social Reward
BDNF-oxytocin interactions in the brain are implicated in mammalian maternal behavior. We found that BDNF gene expression is increased in the hippocampus of rat mothers that show increased pup licking/grooming...
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Article
Open AccessEstrogen receptor α drives pro-resilient transcription in mouse models of depression
Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is ...
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Article
Open AccessEnvironmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus
Early life experience influences stress reactivity and mental health through effects on cognitive-emotional functions that are, in part, linked to gene expression in the dorsal and ventral hippocampus. The hip...
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Article
Erratum: Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans
Correction to: Neuropsychopharmacology Reviews (2012) 38, 111–123; doi:10.1038/npp.2012.149; published online 12 September 2012. In this article, there are errors in the legends of Figures 1, 2, and 3. Below a...
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Article
Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans
Parental care influences development across mammals. In humans such influences include effects on phenotypes, such as stress reactivity, which determine individual differences in the vulnerability for affectiv...
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Article
Impairments in water maze learning of aged rats that received dextromethorphan repeatedly during adolescent period
Dextromethorphan (DM), an over-the-counter cough suppressant, has been recently used as a drug of abuse by teenage groups in some countries, such as the United States, Canada, and Korea. We previously showed t...