13 Result(s)
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Article
Terence S. Dermody
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Open AccessStructure of orthoreovirus RNA chaperone σNS, a component of viral replication factories
The mammalian orthoreovirus (reovirus) σNS protein is required for formation of replication compartments that support viral genome replication and capsid assembly. Despite its functional importance, a mechanis...
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Open AccessPaired immunoglobulin-like receptor B is an entry receptor for mammalian orthoreovirus
Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific pattern...
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Open AccessComparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26.COV2.S
SARS-CoV-2 vaccines BNT162b2, mRNA-1273, and Ad26.COV2.S received emergency use authorization by the U.S. Food and Drug Administration in 2020/2021. Individuals being vaccinated were invited to participate in ...
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Open AccessAuthor Correction: Reovirus directly engages integrin to recruit clathrin for entry into host cells
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Open AccessReovirus directly engages integrin to recruit clathrin for entry into host cells
Reovirus infection requires the concerted action of viral and host factors to promote cell entry. After interaction of reovirus attachment protein σ1 with cell-surface carbohydrates and proteinaceous receptors...
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Open AccessGlycan-mediated enhancement of reovirus receptor binding
Viral infection is an intricate process that requires the concerted action of both viral and host cell components. Entry of viruses into cells is initiated by interactions between viral proteins and their cell...
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Age-dependent susceptibility to reovirus encephalitis in mice is influenced by maturation of the type-I interferon response
Infants and young children are particularly susceptible to viral encephalitis; however, the mechanisms are unknown. We determined the age-dependent contribution of innate and adaptive immune functions to reovi...
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The TRiC chaperonin controls reovirus replication through outer-capsid folding
Viruses are molecular machines sustained through a life cycle that requires replication within host cells. Throughout the infectious cycle, viral and cellular components interact to advance the multistep proce...
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Open AccessValidity of the Medical College Admission Test for predicting MD–PhD student outcomes
The Medical College Admission Test (MCAT) is a quantitative metric used by MD and MD–PhD programs to evaluate applicants for admission. This study assessed the validity of the MCAT in predicting training perfo...
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The sweet spot: defining virus–sialic acid interactions
Many viruses engage sialylated glycans to bind to and infect cells. Sialic acid-binding viruses include influenza virus, reovirus, adenovirus and rotavirus, wh...
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Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
The innate immune receptor RIG-I is shown to sense 5′-diphosphate RNAs as found in some viral genomes in addition to its well characterized activation by RNAs bearing 5′-triphosphate moieties.
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Open AccessAutonomous Reovirus Strain Classification Using Filament-Coupled Antibodies
We previously described a filament-based antibody recognition assay (FARA) that generates ELISA-like sandwich structures immobilized on a filament. FARA allows the coupling of antibodies to precise locations a...
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Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes
To better understand the pathogenesis of herpes simplex virus type 1 (HSV-1) infections of the nervous system, concentrations of F4-neuroprostanes (F4-NP) and F2-isoprostanes (F2-IP) in the murine brain were dete...
