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Chapter
Antioxidants in Prevention and Treatment of Diseases and Toxicity
Oxidative stress reflects an imbalance between the production of reactive oxygen (ROS) and reactive nitrogen species (RNS) and the body’s ability to detoxify their toxic effects through antioxidant defense sys...
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Article
Alterations of blood-brain barrier (BBB) permeability in hyperammonemia: an overview
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Protocol
Measurement of Isoprostanes as Markers of Oxidative Stress
Oxidative stress results from an imbalance between production of reactive oxygen and nitrogen species (ROS and RNS, respectively) and endogenous antioxidant defense mechanisms. Increased generation of ROS/RNS ...
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Protocol
Neuronal Oxidative Injury and Biomarkers of Lipid Peroxidation
Oxidative stress is implicated as one of the major underlying mechanisms in a variety of human diseases. Reactive radicals, derived primarily from molecular oxygen, readily attack a variety of critical biologi...
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Article
A Chronic Iron-Deficient/High-Manganese Diet in Rodents Results in Increased Brain Oxidative Stress and Behavioral Deficits in the Morris Water Maze
Iron deficiency (ID) is especially common in pregnant women and may even persist following childbirth. This is of concern in light of reports demonstrating that ID may be sufficient to produce homeostatic dysr...
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Article
Open AccessApolipoprotein E isoform-dependent dendritic recovery of hippocampal neurons following activation of innate immunity
Innate immune activation, including a role for cluster of differentiation 14/toll-like receptor 4 co-receptors (CD14/TLR-4) co-receptors, has been implicated in paracrine damage to neurons in several neurodege...
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Article
Open AccessNeuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo
The cause-and-effect relationship between innate immune activation and neurodegeneration has been difficult to prove in complex animal models and patients. Here we review findings from a model of direct innate...
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Article
Involvement of nitric oxide in myotoxicity produced by diisopropylphosphorofluoridate (DFP)-induced muscle hyperactivity
Oxidative stress, as determined by increased lipid peroxidation, has been implicated in the pathology of myotoxicity. As a model system to study the response of muscle to oxidative insults, we have studied th...
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Article
Herpes simplex virus type 1 encephalitis is associated with elevated levels of F2-isoprostanes and F4-neuroprostanes
To better understand the pathogenesis of herpes simplex virus type 1 (HSV-1) infections of the nervous system, concentrations of F4-neuroprostanes (F4-NP) and F2-isoprostanes (F2-IP) in the murine brain were dete...
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Article
Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-α-phenylnitrone or vitamin E
Acute effects of seizure-inducing doses of the organophosphate compound diisopropylphosphorofluoridate (DFP, 1.25 mg/kg s.c.) or the carbamate insecticide carbofuran (CF, 1.25 mg/kg s.c.) on nitric oxide (NO)...
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Article
Seizure-induced changes in energy metabolites and effects of N-tert-butyl-α-phenylnitrone (PNB) and vitamin E in rats
Impaired energy metabolism may play a critical role in the neuronal injury caused by kainic acid (KA) induced status epilepticus (SE). Following an acute dose of KA (15 mg/kg, sc) rats developed SE within 1 h...
