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within Article Remove this filter Steven R. Grossman Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. No Access

    Article

    Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target

    The dominant transcriptional regulator of the papiIlomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric ant i para I lei β-barrel. The DNA is severely but smoothly bent ove...

    Rashmi S. Hegde, Steven R. Grossman, Laimonis A. Laimins, Paul B. Sigler in Nature (1992)

  2. No Access

    Article

    Binding and modulation of p53 by p300/CBP coactivators

    The adenovirus E1A and SV40 large-T-antigen oncoproteins bind to members of the p300/CBP transcriptional coactivator family. Binding of p300/CBP is implicated in the transforming mechanisms of E1A and T-antige...

    Nancy L. Lill, Steven R. Grossman, Doron Ginsberg, James DeCaprio… in Nature (1997)

  3. Article

    Open Access

    The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3

    p53 mutations with single amino acid changes in cancer often lead to dominant oncogenic changes. Here, we have developed a mouse model of gain-of-function (GOF) p53-driven lung cancer utilizing conditionally a...

    Catherine A. Vaughan, Shilpa Singh, Mark A. Subler… in Nature Communications (2021)

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