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  1. No Access

    Article

    Topoisomerase IIβ-binding protein 1 activates expression of E2F1 and p73 in HPV-positive cells for genome amplification upon epithelial differentiation

    High-risk human papillomaviruses (HPVs) constitutively activate ataxia telangiectasia mutated (ATM) and ataxia telangiectasia- and Rad3-related (ATR) DNA damage repair pathways for viral genome amplification. ...

    Shiyuan Hong, Junfen Xu, Yan Li, Jorge Andrade, Paul Hoover, Paul J. Kaminski… in Oncogene (2019)

  2. No Access

    Chapter

    The Role of Human Papillomaviruses in Oncogenesis

    Human papillomaviruses (HPVs) are the causative agents of cervical and other anogenital as well as oral cancers. Approximately fifty percent of virally induced cancers in the USA are associated with HPV infect...

    Kristen K. Mighty, Laimonis A. Laimins in Viruses and Human Cancer (2014)

  3. No Access

    Protocol

    Viral Transformation of Epithelial Cells

    Approximately 18% of human cancers have a viral etiology and the majority of these involve transformation of epithelial cells. Viral proteins transform epithelia by inducing alterations in the normal cell grow...

    Jennifer A. Regan, Laimonis A. Laimins in Epithelial Cell Culture Protocols (2013)

  4. No Access

    Article

    Human papillomavirus oncoproteins: pathways to transformation

  5. Human papillomaviruses (HPVs) are the causative agents of over 99% of cervical cancers. Cervical cancer is the second largest cause of cancer deaths in women w...

    6. Cary A. Moody, Laimonis A. Laimins in Nature Reviews Cancer (2010)

  6. No Access

    Chapter

    The Life Cycle of Human Papillomaviruses

    The life cycle of human papillomaviruses (HPV) is dependent on epithelial differentiation and is regulated by a number of cellular proteins. HPVs infect keratinocytes in the basal layer of the epithelium, and ...

    Cary A. Moody, Laimonis A. Laimins in DNA Tumor Viruses (2009)

  7. Article

    Open Access

    Mechanisms regulating expression of the HPV 31 L1 and L2 capsid proteins and pseudovirion entry

    Human papillomaviruses (HPV) infect stratified epithelia and restrict expression of late capsid genes to highly differentiated cells. In order to begin to understand the processes regulating HPV 31 infection w...

    Patrick L Hindmarsh, Laimonis A Laimins in Virology Journal (2007)

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  8. No Access

    Chapter

    The Differentiation-Dependent Life Cycle of Human Papillomaviruses in Keratinocytes

    Choogho Lee, Laimonis A. Laimins in The Papillomaviruses (2007)

  9. No Access

    Protocol

    Human Papillomavirus Type 31 Life Cycle Methods for Study Using Tissue Culture Models

    The life cycle of human papillomaviruses (HPVs) has been difficult to study in tissue culture owing to its dependence on epithelial differentiation. In this chapter several methods are described to imitate the...

    Frauke Fehrmann, Laimonis A. Laimins in DNA Viruses (2005)

  10. No Access

    Article

    Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation

    Human papillomavirus (HPV) infections play a crucial role in the pathogenesis of cervical neoplasia. Insights into the mechanisms by which HPV infection can, in a small numbers of cases, result in malignancy, ...

    Frauke Fehrmann, Laimonis A Laimins in Oncogene (2003)

  11. No Access

    Chapter

    Microarray Analysis of Human Papillomavirus Pathogenesis

    Human papillomaviruses (HPVs) have a complex life cycle, which is associated with the differentiation state of the host cell. Over eighty-five different types have been identified to date, and each exhibits st...

    Yijan Elaine Chang, Laimonis A. Laimins in Pathogen Genomics (2002)

  12. No Access

    Article

    Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

    THE p53 protein is apparently central to the development of human cancers because both alleles are often found to be mutated in different tumour types1. In addition, wild-type p53 can inhibit transformation by vi...

    David H. Mack, Jai Vartikar, James M. Pipas, Laimonis A. Laimins in Nature (1993)

  13. No Access

    Article

    Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target

    The dominant transcriptional regulator of the papiIlomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric ant i para I lei β-barrel. The DNA is severely but smoothly bent ove...

    Rashmi S. Hegde, Steven R. Grossman, Laimonis A. Laimins, Paul B. Sigler in Nature (1992)