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Open AccessThe Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation
The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase activity remain ...
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Article
Open AccessIGF-1R targeting in cancer – does sub-cellular localization matter?
The insulin-like growth factor receptor (IGF-1R) was among the most intensively pursued kinase targets in oncology. However, even after a slew of small-molecule and antibody therapeutics reached clinical trial...
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Article
Open AccessThe EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension
In pulmonary hypertension vascular remodeling leads to narrowing of distal pulmonary arterioles and increased pulmonary vascular resistance. Vascular remodeling is promoted by the survival and proliferation of...
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Article
An opsin 5–dopamine pathway mediates light-dependent vascular development in the eye
During mouse postnatal eye development, the embryonic hyaloid vascular network regresses from the vitreous as an adaption for high-acuity vision. This process occurs with precisely controlled timing. Here, we ...
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Article
Open AccessModeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
Under hypoxic conditions, tumor cells undergo a series of adaptations that promote evolution of a more aggressive tumor phenotype including the activation of DNA damage repair proteins, altered metabolism, and...
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Article
ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis
ETS transcription factor ETV2/Etsrp functions as a key regulator of embryonic vascular development in multiple vertebrates. However, its role in pathological vascular development has not been previously invest...
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Article
Open AccessLinking hypoxia, DNA damage and proliferation in multicellular tumor spheroids
Multicellular Tumor Spheroids are frequently used to mimic the regionalization of proliferation and the hypoxic environment within avascular tumors. Here we exploit these features to study the activation of DN...
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Article
The Eyes Absent proteins in development and disease
The Eyes Absent (EYA) proteins, first described in the context of fly eye development, are now implicated in processes as disparate as organ development, innate immunity, DNA damage repair, photoperiodism, ang...
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Article
A direct and melanopsin-dependent fetal light response regulates mouse eye development
During retinal vascular development there is simultaneous regression of the hyaloid vasculature and formation of the retinal vasculature; here it is demonstrated that regression of develo** vasculature is li...
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Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48
Zubair Ahmed and colleagues identify homozygous mutations in CIB2, a gene that encodes a calcium- and integrin-binding protein, that cause Usher syndrome type 1J and nonsyndromic deafness DFNB48. CIB2 is required...
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Article
Open AccessVariable expressivity of FGF3 mutations associated with deafness and LAMM syndrome
Recessive mutations of fibroblast growth factor 3 (FGF3) can cause LAMM syndrome (OMIM 610706), characterized by fully penetrant complete labyrinthine aplasia, microtia and microdontia.
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Article
Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
House dust mites (Dermatophagoides spp.) are a common cause of allergy, known to trigger asthma attacks. The main dust-mite allergen, Der p 2, is found in high concentrations in mite faecal pellets. Der p 2 has s...
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Article
Eyes absent represents a class of protein tyrosine phosphatases
The Eyes absent proteins are members of a conserved regulatory network implicated in the development of the eye, muscle, kidney and ear1,2,3,4,5,6,7. Mutations in the Eyes absent genes have been associated with s...
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Article
Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DMA-binding domain bound to its DNA target
The dominant transcriptional regulator of the papiIlomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric ant i para I lei β-barrel. The DNA is severely but smoothly bent ove...
