123 Result(s)

Article

Complexity of Chemical Emissions Increases Concurrently with Sexual Maturity in Heliconius Butterflies

Pheromone communication is widespread among animals. Since it is often involved in mate choice, pheromone production is often tightly controlled. Although male sex pheromones (MSPs) and anti-aphrodisiacs have ...

Bruna Cama, Karl Heaton, Jane Thomas-Oates, Stefan Schulz… in Journal of Chemical Ecology (2024)

Article

Hybrid speciation driven by multilocus introgression of ecological traits

Hybridization allows adaptations to be shared among lineages and may trigger the evolution of new species^1,2. However, convincing examples of homoploid hybrid speciation remain rare because it is challenging to d...

Neil Rosser, Fernando Seixas, Lucie M. Queste, Bruna Cama, Ronald Mori-Pezo… in Nature (2024)

Article

O2 supplementation disambiguation in clinical narratives to support retrospective COVID-19 studies

Oxygen saturation, a key indicator of COVID-19 severity, poses challenges, especially in cases of silent hypoxemia. Electronic health records (EHRs) often contain supplemental oxygen information within clinica...

Akhila Abdulnazar, Amila Kugic… in BMC Medical Informatics and Decision Making (2024)

Article

Reply to: How carvedilol does not activate β₂-adrenoceptors

Evi Kostenis, Jesus Gomeza, Elke Miess-Tanneberg… in Nature Communications (2023)

Article

Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach

Somatostatin receptors are clinically validated GPCR biomarkers for diagnosis and treatment of various neuroendocrine tumors (NET). Among the five somatostatin receptors, SST2 and SST3 are associated with apop...

Mor Oron-Herman, David Kirmayer, Amelie Lupp, Stefan Schulz… in Scientific Reports (2023)

Article

Expression of G protein-coupled receptor GPR19 in normal and neoplastic human tissues

Little is known about the expression of the orphan G protein-coupled receptor GPR19 at the protein level. Therefore, we developed a rabbit antibody, targeting human GPR19. After verification of the antibody sp...

Lorena Gerlach, Anna-Sophia Liselott Beyer, Daniel Kaemmerer… in Scientific Reports (2023)

Article

Development of a 5-HT₇ receptor antibody for the rat: the good, the bad, and the ugly

Our laboratory has a vested interest in measuring the location and expression of the 5-hydroxytryptamine (5-HT, serotonin) 7 (5-HT₇) receptor in the rat. Determining tissue-specific receptor expression would aid ...

Janice M. Thompson, Will Tragge… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2023)

Article

Importance of satisfying thermodynamic consistency in optoelectronic device simulations for high carrier densities

We show the importance of using a thermodynamically consistent flux discretization when describing drift–diffusion processes within light emitting diode simulations. Using the classical Scharfetter–Gummel sche...

Patricio Farrell, Julien Moatti, Michael O’Donovan… in Optical and Quantum Electronics (2023)

Article

The uropygial gland of the Great Cormorant (Phalacrocorax carbo): II. Biochemical analysis of the uropygial secretion

In contrast to many other water birds, the Great Cormorant, Phalacrocorax carbo (Phalacrocoracidae), shows a typical wing-spreading behavior after diving. This behavior has been linked to the partial wettability ...

Jonas Holste, Carolin Mügge, Claudia Distler, Stefan Schulz in Journal of Ornithology (2023)

Article

In situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies

G protein-coupled receptors (GPCRs) are important signal transducers that are phosphorylated upon activation at intracellular serine and threonine residues. Although antibodies that specifically recognize the ...

Sebastian Fritzwanker, Falko Nagel, Andrea Kliewer… in Communications Biology (2023)

Article

How Carvedilol activates β₂-adrenoceptors

Carvedilol is among the most effective β-blockers for improving survival after myocardial infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are still unclear. Beyond bl...

Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo… in Nature Communications (2022)

Article

A bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening

Analysis of agonist-driven phosphorylation of G protein-coupled receptors (GPCRs) can provide valuable insights into the receptor activation state and ligand pharmacology. However, to date, assessment of GPCR ...

Johanna Kaufmann, Nina Kathleen Blum, Falko Nagel, Anna Schuler… in Communications Biology (2022)

Article

Reassessment of somatostatin receptor SST4 expression in bronchopulmonary and gastroenteropancreatic neuroendocrine neoplasms using the novel rabbit monoclonal anti-human SST4 antibody 7H49L61

Somatostatin receptors SST1, SST2, and SST5 are overexpressed in neuroendocrine neoplasms (NENs), but little is known about SST4 expression in NENs because of a lack of specific monoclonal antibodies. We recen...

Blanca Ehms, Daniel Kaemmerer, Jörg Sänger, Stefan Schulz… in Scientific Reports (2022)

Article

Comparative evaluation of somatostatin and CXCR4 receptor expression in different types of thyroid carcinoma using well-characterised monoclonal antibodies

Papillary and follicular thyroid carcinomas can be treated surgically and with radioiodine therapy, whereas therapeutic options for advanced stage IV medullary and for anaplastic tumours are limited. Recently,...

Max Czajkowski, Daniel Kaemmerer, Jörg Sänger, Guido Sauter, Ralph M. Wirtz… in BMC Cancer (2022)

Article

Multiscale simulations of uni-polar hole transport in (In,Ga)N quantum well systems

Understanding the impact of the alloy micro-structure on carrier transport becomes important when designing III-nitride-based light emitting diode (LED) structures. In this work, we study the impact of alloy f...

Michael O’Donovan, Patricio Farrell, Timo Streckenbach… in Optical and Quantum Electronics (2022)

Article

Tribute to Professor Kenji Mori and his contribution to Chemical Ecology

David R Hall, Paulo H G Zarbin, Tetsu Ando, Stefan Schulz in Journal of Chemical Ecology (2022)

Article

Cinnamomeoventrolide – Double Bond Regioisomerism in Frog Semiochemicals

Frogs of the families Mantellinae and Hyperoliidae possess male specific femoral or gular glands that are used during courtship. These glands release volatile compounds, e. g. the macrocyclic lactone gephyroma...

Johanna Kuhn, Stefan Schulz in Journal of Chemical Ecology (2022)