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Article
Open AccessIn situ visualization of opioid and cannabinoid drug effects using phosphosite-specific GPCR antibodies
G protein-coupled receptors (GPCRs) are important signal transducers that are phosphorylated upon activation at intracellular serine and threonine residues. Although antibodies that specifically recognize the ...
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Article
Open AccessA bead-based GPCR phosphorylation immunoassay for high-throughput ligand profiling and GRK inhibitor screening
Analysis of agonist-driven phosphorylation of G protein-coupled receptors (GPCRs) can provide valuable insights into the receptor activation state and ligand pharmacology. However, to date, assessment of GPCR ...