5 Result(s)
within
Human Genetics
Reuven Agami
Article
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Article
Open AccessE2F mediates enhanced alternative polyadenylation in proliferation
The majority of mammalian genes contain multiple poly(A) sites in their 3' UTRs. Alternative cleavage and polyadenylation are emerging as an important layer of gene regulation as they generate transcript isofo...
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Article
Open Accessp53 induces transcriptional and translational programs to suppress cell proliferation and growth
Cell growth and proliferation are tightly connected to ensure that appropriately sized daughter cells are generated following mitosis. Energy stress blocks cell growth and proliferation, a critical response fo...
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Article
Open AccessFunctional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence
Functional characterization of non-coding elements in the human genome is a major genomic challenge and the maturation of genome-editing technologies is revolutionizing our ability to achieve this task. Oncoge...
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Article
Open AccessA comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiv...
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Article
Open AccessSuppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors
Accumulating evidence identifies non-genetic mechanisms substantially contributing to drug resistance in cancer patients. Preclinical and clinical data implicate the transcriptional co-activators YAP1 and its ...
