9 Result(s)
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Article
Reuven Agami
Human Genetics
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Article
Molecular mechanisms of non-genetic aberrant peptide production in cancer
The cancer peptidome has long been known to be altered by genetic mutations. However, more recently, non-genetic polypeptide mutations have also been related to cancer cells. These non-genetic mutations occur ...
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Article
Open AccessSuppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors
Accumulating evidence identifies non-genetic mechanisms substantially contributing to drug resistance in cancer patients. Preclinical and clinical data implicate the transcriptional co-activators YAP1 and its ...
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Article
Open AccessA comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis
Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiv...
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Open AccessFunctional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence
Functional characterization of non-coding elements in the human genome is a major genomic challenge and the maturation of genome-editing technologies is revolutionizing our ability to achieve this task. Oncoge...
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Alternative cleavage and polyadenylation: extent, regulation and function
Recent advances in technologies for global map** of alternative polyadenylation (APA) have allowed unprecedented investigation of alternative polyadenylation...
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Article
Open Accessp53 induces transcriptional and translational programs to suppress cell proliferation and growth
Cell growth and proliferation are tightly connected to ensure that appropriately sized daughter cells are generated following mitosis. Energy stress blocks cell growth and proliferation, a critical response fo...
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Open AccessE2F mediates enhanced alternative polyadenylation in proliferation
The majority of mammalian genes contain multiple poly(A) sites in their 3' UTRs. Alternative cleavage and polyadenylation are emerging as an important layer of gene regulation as they generate transcript isofo...
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Article
HBV integrants of hepatocellular carcinoma cell lines contain an active enhancer
Hepatitis B virus (HBV) infection is a major risk factor worldwide for the development of hepatocellular carcinoma (HCC). Integrated HBV DNA fragments, often highly rearranged, are frequently detected in HCC. ...
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Article
The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes
c-Abl, the non-receptor tyrosine kinase is associated with EP, a DNA element found in promoters/enhancers of different viruses and cell-cycle regulated genes. EP-DNA binds RFXI, a member of a novel family of D...
