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Open AccessActivated phosphoinositide 3-kinase δ syndrome caused by PIK3CD mutations: expanding the phenotype
Germline heterozygous gain-of-function (GOF) mutations in the PIK3CD gene lead to a rare primary immunodeficiency disease known as activated phosphoinositide 3-kinase (PI3K) δ syndrome type 1(APDS1). Affected pat...
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Article
Clinical features of CNOT3-associated neurodevelopmental disorder in three Chinese patients
CNOT3 is the central component of the CCR4-NOT protein complex, which is a global regulator of RNA polymerase II transcription. Loss of function mutations in CNOT3 lead to intellectual developmental disorder with...
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Article
Open AccessBig data security access control algorithm based on memory index acceleration in WSNs
The access control is used to ensure these data security when WSN (wireless sensor network) with a large number of base stations transmits huge amount of data to a data center server. Meanwhile big data system...
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Article
Highly Soluble Phenylethynyl-terminated Imide Oligomers and Thermosetting Polyimides Based on 2,2′,3,3′-Biphenyltetracarboxylic Dianhydride
The properties of a series of imide oligomers were characterized according to their molecular weights, solubility, and thermal and rheological properties. This series of imide oligomers was synthesized via a two-...
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Article
Open AccessHuman settlement and regional development in the context of climate change: a spatial analysis of low elevation coastal zones in China
Low elevation coastal zone (LECZ) in China is densely populated and economically developed, which is exposed to increasing risks of hazards related to climate change and sea level rise. To mitigate risks and a...
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Article
Yeast-Incorporated Gallium Attenuates Glucocorticoid-Induced Bone Loss in Rats by Inhibition of Bone Resorption
Glucocorticoids (GC) are potent anti-inflammatory agents and widely used for the treatment of many immune-mediated and inflammatory diseases, whereas GC-induced osteoporosis (GIOP) is the most common cause of ...
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Article
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease
Dongfeng Gu and colleagues report a genome-wide association study for coronary artery disease in Han Chinese individuals. They identify four loci newly associated with coronary artery disease.
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Article
Ginkgo biloba extract enhances glucose tolerance in hyperinsulinism-induced hepatic cells
Ginkgo biloba, an herbal medication, is capable of lowering glucose, fat, and lipid peroxide in diabetic patients. In the current study, we tested the hypothesis that Ginkgo biloba extract (GBE) prevented hyperin...
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Article
An excellent ablative composite based on PBO reinforced EPDM
Short poly(p-phenylene-2,6-benzobisoxazole) (PBO) fibers were first used to reinforce ethylene–propylene–diene terpolymer (EPDM) as thermal insulation materials. The effects of PBO fiber length and content on the...