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Article
Open AccessTlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Toll-like receptor 9 (TLR9) recognizes bacterial, viral and self DNA and play an important role in immunity and inflammation. However, the role of TLR9 in obesity is less well-studied. Here, we generate B-cell...
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Article
Open AccessHSP70 positively regulates translation by interacting with the IRES and stabilizes the viral structural proteins VP1 and VP3 to facilitate duck hepatitis A virus type 1 replication
The maintenance of viral protein homeostasis depends on the interaction between host cell proteins and viral proteins. As a molecular chaperone, heat shock protein 70 (HSP70) has been shown to play an importan...
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Article
Open AccessReal-world evidence from a retrospective study on suicide during depression: clinical characteristics, treatment patterns and disease burden
Suicide stands as both a primary symptom and the direst outcome of major depressive disorder (MDD). The scarcity of effective treatment strategies makes managing MDD patients with suicide especially challengin...
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Article
Open AccessPlasma Epstein-Barr virus microRNA BART8-3p as a potential biomarker for detection and prognostic prediction in early nasopharyngeal carcinoma
Epstein-Barr virus (EBV) encoded microRNA BART8-3p (miR-BART8-3p) was significantly associated with the metastasis in nasopharyngeal carcinoma (NPC). To explore the clinical values of plasma miR-BART8-3p in pa...
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Article
Analysis on the causes of massive stranding of Yellow Sea green tide on Lianyungang and Rizhao coasts in 2022
In 2022, Yellow Sea green tide caused by Ulva prolifera reached a historic minimum and the coastal areas of Shandong Peninsula were less affected. However, the largest amount of seaweed biomass has been washed as...
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Article
Investigation of the Constitutive Damage Model of Rock Under the Coupled Effect of Freeze–Thaw Cycles and Loading
Understanding the mechanism of disasters and designing protection systems for cold region tunnels require a fundamental analysis of the constitutive model of rock under freeze–thaw (FT) cycles and loading. In ...
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Article
Edaravone Maintains AQP4 Polarity Via OS/MMP9/β-DG Pathway in an Experimental Intracerebral Hemorrhage Mouse Model
Oxidative stress (OS) is the main cause of secondary damage following intracerebral hemorrhage (ICH). The polarity expression of aquaporin-4 (AQP4) has been shown to be important in maintaining the homeostasis...
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Article
Conservation Strategies for Aquilaria sinensis: Insights from DNA Barcoding and ISSR Markers
The evergreen tree species Aquilaria sinensis holds significant economic importance due to its specific medicinal values and increasing market demand. However, the unrestricted illegal exploitation of its wild po...
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Article
Different indicative roles of stable nitrogen isotope in soil N dynamics of tropical leguminous and non-leguminous forests following nutrient addition
Plant and soil nitrogen (N) isotope ratios (δ15N) have been used as indicators of N cycling processes of ecosystems. However, the effects of N and Phosphorus (P) addition on δ15N values and their indicative roles...
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Article
Aerobic Glycolysis Induced by mTOR/HIF-1α Promotes Early Brain Injury After Subarachnoid Hemorrhage via Activating M1 Microglia
M1 microglial activation is crucial for the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH), and there is growing evidence that glucose metabolism is frequently involved in mic...
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Article
Open AccessActivated phosphoinositide 3-kinase δ syndrome caused by PIK3CD mutations: expanding the phenotype
Germline heterozygous gain-of-function (GOF) mutations in the PIK3CD gene lead to a rare primary immunodeficiency disease known as activated phosphoinositide 3-kinase (PI3K) δ syndrome type 1(APDS1). Affected pat...
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Article
Open AccessGenome-wide association study reveals serovar-associated genetic loci in Riemerella anatipestifer
The disease caused by Riemerella anatipestifer (R. anatipestifer, RA) results in large economic losses to the global duck industry every year. Serovar-related genomic variation, such as the O-antigen and capsular...
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Article
Open AccessRenal-protective effects of Chinese medicinal herbs and compounds for diabetic kidney disease in animal models: protocol for systematic review and meta-analysis
Diabetic kidney disease (DKD) is a common and severe complication of diabetes that can lead to end-stage renal disease with no cure. The first-line drugs recommended by clinical guidelines fail to achieve sati...
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Article
Open AccessCharacteristics of the a sequence of the duck Plague virus genome and specific cleavage of the viral genome based on the a sequence
During the replication process, the herpesvirus genome forms the head-to-tail linked concatemeric genome, which is then cleaved and packaged into the capsid. The cleavage and packing process is carried out by ...
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Protocol
Detection of dsRNA with Fluorescence In Situ Hybridization (FISH)
Fluorescence in situ hybridization (FISH) is a powerful technique used for detecting and localizing specific nucleic acid sequences in cells or tissues. Double-stranded RNA (dsRNA) is a type of RNA with comple...
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Article
Biomimetic modification strategy of nitrate glycerol ether cellulose with polydopamine and its thermal decomposition behavior
Nitrate glycerol ether cellulose (NGEC) is a potential cellulose substitute for the substrate of gun propellants in the future, but interfacial compatibility with high energy solid filler has remained an ongoi...
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Article
Chaetomium elatum treatment of nitrocellulose: investigation on structural and thermal properties
Biological methods present a sustainable approach for treating various waste polymers due to green, low-cost, mild condition and simple operation. This study, a novel biological method to process nitrocellulos...
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Article
Open AccessAssociation between serum PCSK9 and coronary heart disease in patients with type 2 diabetes mellitus
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is considered a new biomarker for atherosclerosis, but its ability to predict cardiovascular outcomes has been controversial. This study aimed to address t...
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Article
Numerical Study on the Damage Characteristics of Layered Shale Using 3D DEM
Layered shale is a kind of rock with obvious anisotropy, which is significantly influenced by the inclination angle of the rock. In this study, the influence of bedding dip on the strength characteristics, fai...
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Article
Open AccessGenome characteristics of atypical porcine pestivirus from abortion cases in Shandong Province, China
Atypical porcine pestivirus (APPV) is a novel, highly variable porcine pestivirus. Previous reports have suggested that the virus is associated with congenital tremor (CT) type A-II in piglets, and little info...
