47 Result(s)
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Article
Pradeep K Singh
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Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
The bacterium Pseudomonas aeruginosa permanently colonizes cystic fibrosis lungs despite aggressive antibiotic treatment1,2,3. This suggests that P. aeruginosa might exist as biofilms—structured communities of ba...
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A component of innate immunity prevents bacterial biofilm development
Antimicrobial factors form one arm of the innate immune system, which protects mucosal surfaces from bacterial infection1,2,3. These factors can rapidly kill bacteria deposited on mucosal surfaces and prevent acu...
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Iron sequestration by human lactoferrin stimulates P. aeruginosa surface motility and blocks biofilm formation
This paper summarizes a presentation at the 6th International Conference on Lactoferrin Structure and Function. Some of this data has been previously published.
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The Mercury(II) Catalyzed Ligand Exchange Between Hexacyanoferrate(II) and Pyrazine in Aqueous Medium
The kinetic and mechanistic studies of HgII catalyzed exchange of coordinated cyanide in hexacyanoferrate(II) by pyrazine (Pz) were monitored by following the appearance of the yellow complex [Fe(CN)5Pz]3− at 440...
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Single-copy genes define a conserved order between rice and wheat for understanding differences caused by duplication, deletion, and transposition of genes
The high-quality rice genome sequence is serving as a reference for comparative genome analysis in crop plants, especially cereals. However, early comparisons with bread wheat showed complex patterns of conser...
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Kinetic determination of silver at trace level based on its catalytic effect on a ligand substitution reaction
It is observed that Ag(I) catalyzes the rate of substitution of phenylhydrazine (PhNHNH2) into hexacyanoferrate(II), producing a cherry red colored complex, [Fe(CN)5PhNHNH2]3−. The reaction was monitored at 488 n...
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SNP haplotypes of the BADH1 gene and their association with aroma in rice (Oryza sativa L.)
Betaine aldehyde dehydrogenase (BADH) is a key enzyme involved in the synthesis of glycinebetaine—a powerful osmoprotectant against salt and drought stress in a large number of species. Rice is not known to ac...
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Amyloid-Like Fibril Formation by Tachykinin Neuropeptides and Its Relevance to Amyloid β-Protein Aggregation and Toxicity
Protein aggregation and amyloid formation are associated with both pathological conditions in humans such as Alzheimer’s disease and native functions such as peptide hormone storage in the pituitary secretory ...
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Prediction of Surface Roughness in Turning of EN 353 Using Response Surface Methodology
In the present work, an attempt has been made to investigate the influence of cutting speed, feed, depth of cut and nose radius on surface roughness during wet turning of EN 353 steel using tungsten carbide in...
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An improved surface roughness prediction model using Box-Cox transformation with RSM in end milling of EN 353
In the present work, an attempt has been made to use Box-Cox transformation with response surface methodology to develop improve surface roughness prediction model in end milling of EN 353 steel using carbide ...
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Open AccessStructure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation
Mechanistic understanding of nucleation dependent polymerization by α-synuclein (α-Syn) into toxic oligomers and amyloids is important for the drug development against Parkinson's disease. However the structur...
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Open AccessEffect of Allelic Variation in Triticin on Bread- and Chapati-Making Qualities of Wheat (Triticum aestivum)
Triticin, a legumin-like storage protein of wheat endosperm, was discovered nearly three decades ago but so far there is no report on its effect on the processing quality of wheat that is thought to be determi...
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Precision-engineering the Pseudomonas aeruginosa genome with two-step allelic exchange
Here, the authors describe genetically engineering the Pseudomonas genome by two-step allelic exchange. Suicide vector-encoded alleles are used to generate mutations by homologous recombination at the single base...
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Open AccessEffect of curcumin analogs onα-synuclein aggregation and cytotoxicity
Alpha-synuclein (α-Syn) aggregation into oligomers and fibrils is associated with dopaminergic neuron loss occurring in Parkinson’s disease (PD) pathogenesis. Compounds that modulate α-Syn aggregation and inte...
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Open AccessImplantable amyloid hydrogels for promoting stem cell differentiation to neurons
We report a new class of amyloid-inspired peptide hydrogels that was designed and based on α-synuclein protein for which hydrogel formation is triggered by various stimuli, such as heating/cooling or changes i...
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Open AccessIn vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075
The nosocomial pathogen Acinetobacter baumannii is a frequent cause of hospital-acquired infections worldwide and is a challenge for treatment due to its evolved resistance to antibiotics, including carbapenems. ...
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Kinetic Energy Recovery from the Chimney Flue Gases Using Ducted Turbine System
An innovative idea of extracting kinetic energy from man-made wind resources using ducted turbine system for on-site power generation is introduced in this paper. A horizontal axis ducted turbine is attached t...
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Numerical modelling-based pillar strength estimation for an increased height of extraction
Underground extraction of total thickness of a thick coal seam in single lift by bord and pillar method increases pillar height during retreat. Field studies found that the increase in pillar height affects th...
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Open AccessStructure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes
Proteasome inhibitors benefit patients with multiple myeloma and B cell-dependent autoimmune disorders but exert toxicity from inhibition of proteasomes in other cells. Toxicity should be minimized by reversib...
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Open AccessGenetic interaction involving photoperiod-responsive Hd1 promotes early flowering under long-day conditions in rice
Although flowering in rice has been extensively investigated, few studies focused on genetic interactions. Flowering evaluation of two recombinant inbred line (RIL) populations involving photo-insensitive rice...
