16 Result(s)
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Article
Mutsuo Harada
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Open AccessLow-carbohydrate diets containing plant-derived fat but not animal-derived fat ameliorate heart failure
Cardiovascular disease (CVD) is a global health burden in the world. Although low-carbohydrate diets (LCDs) have beneficial effects on CVD risk, their preventive effects remain elusive. We investigated whether...
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Open AccessSpatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction
The underlying mechanisms of ventricular remodeling after myocardial infarction (MI) remain largely unknown. In this study, we performed an integrative analysis of spatial transcriptomics and single-nucleus RN...
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Open AccessCardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis
Tissue fibrosis and organ dysfunction are hallmarks of age-related diseases including heart failure, but it remains elusive whether there is a common pathway to induce both events. Through single-cell RNA-seq,...
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Open AccessAuthor Correction: CXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessCXCR7 ameliorates myocardial infarction as a β-arrestin-biased receptor
Most seven transmembrane receptors (7TMRs) are G protein-coupled receptors; however, some 7TMRs evoke intracellular signals through β-arrestin as a biased receptor. As several β-arrestin-biased agonists have b...
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Open AccessFactors associated with left ventricular reverse remodelling after percutaneous coronary intervention in patients with left ventricular systolic dysfunction
Percutaneous coronary intervention (PCI) is sometimes considered as an alternative therapeutic strategy to surgical revascularization in patients with coronary artery disease (CAD) and reduced left ventricular...
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Open AccessOmega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart
Some clinical trials showed that omega-3 fatty acid (FA) reduced cardiovascular events, but it remains unknown whether omega-3 FA supplementation changes the composition of FAs and their metabolites in the hea...
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A metabolic profile of routine needle biopsies identified tumor type specific metabolic signatures for breast cancer stratification: a pilot study
Metabolomics has recently emerged as a tool for understanding comprehensive tumor-associated metabolic dysregulation. However, only limited application of this technology has been introduced into the clinical ...
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Open AccessCardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte remodeling and clarify distinct...
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Open AccessAuthor Correction: Activation of endothelial β-catenin signaling induces heart failure
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Open AccessGenetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling
Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) are genetically and phenotypically heterogeneous. Cardiac function is improved after treatment in some cardiomyopathy patients, but little is ...
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Open AccessActivation of endothelial β-catenin signaling induces heart failure
Activation of β-catenin-dependent canonical Wnt signaling in endothelial cells plays a key role in angiogenesis during development and ischemic diseases, however, other roles of Wnt/β-catenin signaling in endo...
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Open AccessPDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium
Cardiac progenitor/stem cells in adult hearts represent an attractive therapeutic target for heart regeneration, though (inter)-relationships among reported cells remain obscure. Using single-cell qRT–PCR and ...
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p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
Cardiac enlargement, or hypertrophy, is a physiological response to increased workload and helps to maintain cardiac function. If the condition is prolonged, however, it can develop into heart failure. New ins...
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Azelnidipine Inhibits H2O2-Induced Cell Death in Neonatal Rat Cardiomyocytes
Oxidative stress plays an important role in the pathogenesis of cardiovascular diseases. Azelnidipine is a novel dihydropyridine calcium channel blocker. Several studies have demonstrated that some dihydropyri...
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G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
Granulocyte colony-stimulating factor (G-CSF) was reported to induce myocardial regeneration by promoting mobilization of bone marrow stem cells to the injured heart after myocardial infarction, but the precis...
