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Open AccessAssessment of left ventricular tissue mitochondrial bioenergetics in patients with stable coronary artery disease
Recurrent myocardial ischemia can lead to left ventricular (LV) dysfunction in patients with coronary artery disease (CAD). In this observational cohort study, we assessed for chronic metabolomic and transcrip...
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Article
Open AccessSpatially resolved multiomics of human cardiac niches
The function of a cell is defined by its intrinsic characteristics and its niche: the tissue microenvironment in which it dwells. Here we combine single-cell and spatial transcriptomics data to discover cellul...
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Article
Single-cell transcriptomics for the assessment of cardiac disease
Cardiovascular disease is the leading cause of death globally. An advanced understanding of cardiovascular disease mechanisms is required to improve therapeutic strategies and patient risk stratification. Stat...
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Article
Decoding Covid-19 with the SARS-CoV-2 Genome
SARS-CoV-2, the recently emerged coronavirus (CoV) that is responsible for the current global pandemic Covid-19, first appeared in late 2019 in Wuhan, China. Here, we summarise details of the SARS-CoV-2 genome...
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Open AccessCells of the adult human heart
Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the he...
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Open AccessHuman pluripotent stem cell-derived cardiomyocytes as a target platform for paracrine protection by cardiac mesenchymal stromal cells
Ischemic heart disease remains the foremost cause of death globally, with survivors at risk for subsequent heart failure. Paradoxically, cell therapies to offset cardiomyocyte loss after ischemic injury improv...
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Epicardial FSTL1 reconstitution regenerates the adult mammalian heart
The elucidation of factors that activate the regeneration of the adult mammalian heart is of major scientific and therapeutic importance. Here we found that epicardial cells contain a potent cardiogenic activi...
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Open AccessPDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium
Cardiac progenitor/stem cells in adult hearts represent an attractive therapeutic target for heart regeneration, though (inter)-relationships among reported cells remain obscure. Using single-cell qRT–PCR and ...
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Where did the scientific method go?
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Erratum: Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
Nature 407, 592 — 598 (2000). The name of one author, Yoshifumi Yokota, was inadvertently omitted from the author list but is included above. He is affiliated with the Department of Biochemistry, Fukui Medical...
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Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins
In mammalian cells, Id proteins coordinate proliferation and differentiation. Id2 is a dominant-negative antagonist of basic helix–loop–helix transcription factors and proteins of the retinoblastoma (Rb) famil...
