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Article
Open AccessTet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes
β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). Here we report a role of their expression of Tet2 in regulating immune killing. Tet2 is induced in murine and human β ce...
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Article
Author Correction: Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice
A recent epidemic of Zika virus in the Americas, affecting well over a million people, caused substantial mortality and morbidity, including Guillain–Barre syndrome, microcephaly and other fetal developmental ...
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Article
Open AccessEnhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis
Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains uncl...
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Article
Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity
Foxp3+ regulatory T cells (Treg cells) are the central component of peripheral immune tolerance. Whereas a dysregulated Treg cytokine signature has been observed in autoimmune diseases, the regulatory mechanisms ...
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Article
Open AccessCardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure
Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte remodeling and clarify distinct...
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Article
Open AccessAuthor Correction: Activation of endothelial β-catenin signaling induces heart failure
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessDNA single-strand break-induced DNA damage response causes heart failure
The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed in the failing heart, however, the type of DNA damage and its role in the pathogen...
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Article
Open AccessActivation of endothelial β-catenin signaling induces heart failure
Activation of β-catenin-dependent canonical Wnt signaling in endothelial cells plays a key role in angiogenesis during development and ischemic diseases, however, other roles of Wnt/β-catenin signaling in endo...
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Article
Open AccessAngiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression
Disruption of angiotensin II type 1 (AT1) receptor prolonged life span in mice. Since aging-related decline in skeletal muscle function was retarded in Atgr1a−/− mice, we examined the role of AT1 receptor in musc...
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Article
Open AccessComplement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling
Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallm...
