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Article
Air pollution and occupational accidents in the Community of Madrid, Spain
Spain is the EU member country with the third highest total number of accidents in work and has the third highest incidence rate. We have performed a descriptive analysis of occupational accidents in the Commu...
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Article
The genetic profile of bone marrow transplant patients in different samples of forensic interest
Humans constantly lose epithelial cells, and these biological traces are frequently studied in the context of criminal investigations. The objective of this work was to examine the genetic profile in samples o...
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Article
Who is legally responsible for deaths caused by air pollution?
A person’s death is deemed unnatural when it is the result of an external force. This definition, however, does not apply when the cause of death is a respiratory or cardiovascular process triggered by a high ...
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Article
Association Between Suicide and Environmental Variables in the North of Spain: A 14-Year Analysis
Suicide is a serious public health problem around the world. Since the nineteenth century, the impact of socio-environmental factors on suicide has attracted much public attention, especially in the context of...
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Article
Integrating and analyzing medical and environmental data using ETL and Business Intelligence tools
Processing data that originates from different sources (such as environmental and medical data) can prove to be a difficult task, due to the heterogeneity of variables, storage systems, and file formats that c...
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Article
Non-synonymous WNT16 polymorphisms alleles are associated with different osteoarthritis phenotypes
Hereditary factors have a strong influence on osteoarthritis (OA). The Wnt pathway is involved in bone and cartilage homeostasis. Hence, we hypothesized that allelic variations of WNT16 could influence the OA ...
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Article
Open AccessAnalysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 R1b-DF2...
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Article
Stroke: Temporal Trends and Association with Atmospheric Variables and Air Pollutants in Northern Spain
Stroke, the second cause of death and the most frequent cause of severe disability among adults in developed countries, is related to a large variety of risk factors. This paper assesses the temporal patterns ...
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Article
Indel analysis by droplet digital PCR: a sensitive method for DNA mixture detection and chimerism analysis
Several methods have been developed to determinate genetic profiles from a mixed samples and chimerism analysis in transplanted patients. The aim of this study was to explore the effectiveness of using the dro...
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Article
The Influence of Nitrogen Dioxide on Arrhythmias in Spain and Its Relationship with Atmospheric Circulation
Epidemiological studies suggest that increased ambient NO2 concentrations are associated with cardiovascular disease. However, none of them have examined the association between ambient air pollution and cardiac ...
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Article
Osterix and RUNX2 are Transcriptional Regulators of Sclerostin in Human Bone
Sclerostin, encoded by the SOST gene, works as an inhibitor of the Wnt pathway and therefore is an important regulator of bone homeostasis. Due to its potent action as an inhibitor of bone formation, blocking scl...
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Article
Exon array analysis reveals genetic heterogeneity in atypical femoral fractures. A pilot study
Atraumatic subtrochanteric and diaphyseal (atypical) femoral fractures are a rare, but important adverse event in patients treated with potent anti-resortive agents. The mechanisms involved are unknown and par...
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Article
Polymorphisms of the farnesyl diphosphate synthase gene modulate bone changes in response to atorvastatin
Although their primary therapeutic indications are different, aminobisphosphonates and statins target enzymes in the mevalonate pathway, which is critical for bone homeostasis. Previous studies have shown tha...
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Article
A Sclerostin Super-Producer Cell Line Derived from the Human Cell Line SaOS-2: A New Tool for the Study of the Molecular Mechanisms Driving Sclerostin Expression
Sclerostin, the product of the SOST gene, is a key regulator of bone homeostasis. Sclerostin interferes with the Wnt signalling pathway and, therefore, has a negative effect on bone formation. Although the imp...
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Article
Wnt-related genes and large-joint osteoarthritis: association study and replication
Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide pol...
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Article
Development and validation of a multiplex reaction analyzing eight miniSTRs of the X chromosome for identity and kinship testing with degraded DNA
We report the development of an effective system for analyzing X chromosome-linked mini short tandem repeat loci with reduced-size amplicons (less than 220 bp), useful for analyzing highly degraded DNA samples...
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Article
miRNA analysis in vitreous humor to determine the time of death: a proof-of-concept pilot study
We hypothesized that miRNAs present in vitreous humor could be a sort of “biological black box,” storing information about physiological and environmental circumstances at death. As a proof of concept, we anal...
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Article
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Fernando Rivadeneira and colleagues in the Genetic Factors for Osteoporosis Consortium report a large-scale meta-analysis identifying new loci associated with bone mineral density (BMD) and risk of fracture. T...
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Article
Open AccessHaplotypes of intron 4 of the estrogen receptor alpha gene and hip fractures: a replication study in Caucasians
Despite their great impact, few genetic association studies have used hip fractures as an endpoint. However, the association of two polymorphisms on intron 4 of estrogen receptor alpha (ESR1) with hip fractures w...
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Article
Open AccessGenetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women
Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues. The objective of this study w...