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Article
Wnt-related genes and large-joint osteoarthritis: association study and replication
Osteoarthritis (OA) has a strong genetic component, and experimental evidence suggests the involvement of the Wnt pathway in its pathogenesis. Hence, we explored the association of common single nucleotide pol...
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Article
Clonazepam for seizure prophylaxis in adult patients treated with high dose busulfan
Background Due to their favorable toxicity profile and lack of interactions, benzodiazepines have been proposed as prophylaxis of busulfan induced seizures. Although they are broadly used in pedi...
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Chapter
High Capacity Flexible Systems for Slope Stabilization in La Gomera (Spain)
The information contained in this document refers to the use of high capacity flexible systems for slope stabilizations in volcanic terrains in La Gomera (Canary Islands – Spain). On the TF-711 road, civil job...
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Article
Treating Epiphora in Adults With the Wilhelm Plastic Nasolacrimal Stent: Mid-Term Results of a Prospective Study
The objective of the present study was to evaluate, in a prospective, single-center study, the effectiveness of the Wilhelm-type stent used in interventional radiology for the management of epiphora. Patients (n ...
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Article
Semisynthesis of novel monacolin J derivatives: hypocholesterolemic and neuroprotective activities
A fungal strain able to naturally accumulate large amounts of monacolin J was improved by N-methyl-N′-nitro-N-nitrosoguanidine mutagenesis and genetic disruption of the lovF gene. Semisynthesis was then used to p...
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Article
Open AccessHaplotypes of intron 4 of the estrogen receptor alpha gene and hip fractures: a replication study in Caucasians
Despite their great impact, few genetic association studies have used hip fractures as an endpoint. However, the association of two polymorphisms on intron 4 of estrogen receptor alpha (ESR1) with hip fractures w...
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Article
Short-chain fructooligosaccharides, in spite of being fermented in the upper part of the large intestine, have anti-inflammatory activity in the TNBS model of colitis
Previous studies have demonstrated the anti-inflammatory effect of fructooligosaccharides (FOS) on intestinal inflammation. The aim of the present study was to elucidate whether the colonic fermentation of the...
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Protocol
Screening of Microorganisms for Enzymatic Biosynthesis of Nondigestible Oligosaccharides
Nondigestible oligosaccharides (NDOs), namely prebiotic oligosaccharides, are functional food ingredients that possess properties that are beneficial to the health of consumers. These include noncariogenicity,...
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Article
Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum
Medically useful semisynthetic cephalosporins are made from 7-aminodeacetoxycephalosporanic acid (7-ADCA) or 7-aminocephalosporanic acid (7-ACA). Here we describe a new industrially amenable bioprocess for the...
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Article
Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins
The genespcbAB,pcbC andpenDE encoding the enzymes (α-aminoadipyl-cysteinyl-valine synthetase, isopenicillin N synthase and isopenicillin N acyltransferase, respectively) involved in the biosynthesis of penicillin...
