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Durable, colored and dual crosslinking networks constructed in Lyocell cellulose structure for high-quality greener textiles
As a good alternative to natural fibers and petroleum-derived fibers, Lyocell fibers draw increasing interests owing to its advantages of sustainable forest source, low carbon emission, high strength and comfo...
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Open AccessWhole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation
Chinese indigenous sheep are valuable resources with unique features and characteristics. They are distributed across regions with different climates in mainland China; however, few reports have analyzed the e...
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Open AccessPreparation, characterization and in vivo pharmacokinetic study of ginsenoside Rb1-PLGA nanoparticles
This study aimed to construct a Ginsenoside Rb1-PLGA nano drug delivery system, optimize its preparation process, characterize and evaluate the resulting Ginsenoside Rb1-PLGA Nanoparticles (GRb1@PLGA@NPs). GRb...
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Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
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GLP1RAs vs SGLT2is were associated with lower risk of major adverse limb events and similar risks of heart failure hospitalisation and stroke?
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Open AccessA comparative study between deep learning and radiomics models in grading liver tumors using hepatobiliary phase contrast-enhanced MR images
To compare a deep learning model with a radiomics model in differentiating high-grade (LR-3, LR-4, LR-5) liver imaging reporting and data system (LI-RADS) liver tumors from low-grade (LR-1, LR-2) LI-RADS tumor...
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Correction to: Does evidence from RCTs suggest: SGLT2 inhibitors could not reduce myocardial infarction and stroke?
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Does evidence from RCTs suggest: SGLT2 inhibitors could not reduce myocardial infarction and stroke?
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Open AccessGenome of the webworm Hyphantria cunea unveils genetic adaptations supporting its rapid invasion and spread
The fall webworm Hyphantria cunea is an invasive and polyphagous defoliator pest that feeds on nearly any type of deciduous tree worldwide. The silk web of H. cunea aids its aggregating behavior, provides thermal...
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Open AccessGenome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays
Chinese indigenous sheep can be classified into three types based on tail morphology: fat-tailed, fat-rumped, and thin-tailed sheep, of which the typical breeds are large-tailed Han sheep, Altay sheep, and Tib...
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Open AccessGenome-wide analysis reveals adaptation to high altitudes in Tibetan sheep
Tibetan sheep have lived on the Tibetan Plateau for thousands of years; however, the process and consequences of adaptation to this extreme environment have not been elucidated for important livestock such as ...
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Open AccessRosa26-targeted sheep gene knock-in via CRISPR-Cas9 system
Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made rela...
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Open AccessDNA methylation Landscape of body size variation in sheep
Sub-populations of Chinese Mongolian sheep exhibit significant variance in body mass. In the present study, we sequenced the whole genome DNA methylation in these breeds to detect whether DNA methylation plays...
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Open AccessDetection of selection signatures in dairy and beef cattle using high-density genomic information
Artificial selection for economically important traits in cattle is expected to have left distinctive selection signatures on the genome. Access to high-density genotypes facilitates the accurate identificatio...
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Open AccessGenome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds
Traditionally, Chinese indigenous sheep were classified geographically and morphologically into three groups: Mongolian, Kazakh and Tibetan. Herein, we aimed to evaluate the population structure and genome sel...
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Genomic sequencing identifies novel Bacillus thuringiensis Vip1/Vip2 binary and Cry8 toxins that have high toxicity to Scarabaeoidea larvae
The Bacillus thuringiensis strain HBF-18 (CGMCC 2070), which has previously been shown to encode the cry8Ga toxin gene, is active against both Holotrichia oblita and Holotrichia parallela. Recombinant Cry8Ga howe...
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Open AccessAAV2-mediated follistatin overexpression induces ovine primary myoblasts proliferation
Follistatin (FST) has been shown to bind to some TGF-β family members and can function as a potent myostatin (MSTN) antagonist. Recent studies have revealed that over-expression of FST by adeno-associated viru...
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Screening of cry-type promoters with strong activity and application in Cry protein encapsulation in a sigK mutant
To optimize the expression of cry genes in a Bacillus thuringiensis sigK mutant failing in crystal releasing, the transcriptional activity of the cry promoters cry1A, cry3A, cry4A, and cry8E was compared using la...
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Open AccessComparison of single-trait and multiple-trait genomic prediction models
In this study, a single-trait genomic model (STGM) is compared with a multiple-trait genomic model (MTGM) for genomic prediction using conventional estimated breeding values (EBVs) calculated using a conventio...
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Cloning and expression of MyoG gene from Hu sheep and identification of its myogenic specificity
This experiment was conducted to explore the biological functions of myogenin (MyoG) gene. MyoG gene was cloned from genome of Hu sheep by overlap extension PCR. Then, pEGFP-C1–MyoG and pcDNA3.0–MyoG fusion expre...