8 Result(s)

Article

Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study

Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based b...

Frederic Brosseron, Anne Maass, Luca Kleineidam… in Alzheimer's Research & Therapy (2023)

Article

Medin co-aggregates with vascular amyloid-β in Alzheimer’s disease

Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of age^1,2, making it the most common amyloid currently kno...

Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros… in Nature (2022)

Article

Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae

Brain Aβ deposition is a key early event in the pathogenesis of Alzheimer´s disease (AD), but the long presymptomatic phase and poor correlation between Aβ deposition and clinical symptoms remain puzzling. To ...

Christine Rother, Ruth E. Uhlmann, Stephan A. Müller… in Nature Communications (2022)

Article

CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles

Stephan A. Kaeser, Lisa M. Häsler, Marius Lambert, Carina Bergmann… in Acta Neuropathologica (2022)

Article

Cerebrospinal fluid cytokine levels are associated with macrophage infiltration into tumor tissues of glioma patients

Diffuse gliomas are the most common malignant tumors of the central nervous system with poor treatment efficacy. Infiltration of immune cells into tumors during immunosurveillance is observed in multiple tumor...

Constanze L. Kemmerer, Jens Schittenhelm, Evelyn Dubois, Laura Neumann… in BMC Cancer (2021)

Article

Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures

Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of ...

Melanie Barth, Mehtap Bacioglu, Niklas Schwarz… in Molecular Neurodegeneration (2021)