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Multivitamin use after diagnosis and prostate cancer survival among men with nonmetastatic prostate cancer
Multivitamin use is common among cancer patients. Whether post-diagnostic multivitamin supplementation is beneficial for prostate cancer survival is largely unknown, and some evidence even suggests potential h...
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Article
Modifiable risk factors for subsequent lethal prostate cancer among men with an initially negative prostate biopsy
Previously suggested modifiable risk factors for prostate cancer could have resulted from detection bias because diagnosis requires a biopsy. We investigated modifiable risk factors for a subsequent cancer dia...
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Article
Open AccessStatins and prostate cancer—hype or hope? The epidemiological perspective
Men using cholesterol-lowering statin medications have been found to have lower risks of both advanced and fatal prostate cancer in multiple registry-based studies and prospective cohort studies. Statin use ha...
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Open AccessAZIN1 RNA editing alters protein interactions, leading to nuclear translocation and worse outcomes in prostate cancer
The transcript encoding Antizyme Inhibitor 1 (AZIN1) is frequently edited in various cancers, and this editing is associated with enhanced tumor aggressiveness. After comparison of wild-type AZIN1 (wtAZIN1) an...
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Article
In search of the optimal setting for statin trials in prostate cancer: the power of population-based studies
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Article
Cancer therapy shapes the fitness landscape of clonal hematopoiesis
Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of...
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Open AccessThe association of diabetes with risk of prostate cancer defined by clinical and molecular features
To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features.
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Regular aspirin use and gene expression profiles in prostate cancer patients
Pharmacoepidemiology studies suggest prognostic benefits of aspirin in prostate cancer. We hypothesized that aspirin induces transcriptional changes in tumors or normal prostate tissue.
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Metformin and prostate cancer mortality: a meta-analysis
Observational studies report conflicting results on the association between metformin exposure and prostate cancer outcomes. This meta-analysis summarizes studies reporting overall survival, prostate cancer-sp...