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Article
Socioenvironmental adversity and risk of prostate cancer in non-Hispanic black and white men
Non-Hispanic black (NHB) men experience higher risk of prostate cancer than other racial/ethnic groups, and it is possible that socioenvironmental (SE) adversity and resulting stress may contribute to this dis...
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Article
Regular aspirin use and gene expression profiles in prostate cancer patients
Pharmacoepidemiology studies suggest prognostic benefits of aspirin in prostate cancer. We hypothesized that aspirin induces transcriptional changes in tumors or normal prostate tissue.
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Article
Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer
Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate canc...
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Chapter
Cancer Screening
The goal of cancer screening is to detect disease earlier in its development, allowing earlier treatment and presumably decreased morbidities and mortality associated with the later expression of more advanced...
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Article
Open AccessThe role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study
Understanding the biologic mechanisms underlying the development of lethal prostate cancer is critical for improved therapeutic and prevention strategies. In this study we explored the role of tumor metabolism...
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Article
Vascular morphology differentiates prostate cancer mortality risk among men with higher Gleason grade
Higher Gleason grade is associated with prostate cancer mortality; however, there is significant heterogeneity in this association. We evaluated whether vessel morphology, a biomarker of angiogenesis, aided in...
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Article
Open AccessErratum to: Frequency and ty** of Propionibacterium acnes in prostate tissue obtained from men with and without prostate cancer
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Article
Open AccessFrequency and ty** of Propionibacterium acnes in prostate tissue obtained from men with and without prostate cancer
Prostate cancer is the most common cancer among men in Western countries but the exact pathogenic mechanism of the disease is still largely unknown. An infectious etiology and infection-induced inflammation ha...
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Article
Metformin and prostate cancer mortality: a meta-analysis
Observational studies report conflicting results on the association between metformin exposure and prostate cancer outcomes. This meta-analysis summarizes studies reporting overall survival, prostate cancer-sp...
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Article
Circadian clock genes and risk of fatal prostate cancer
Circadian genes may be involved in regulating cancer-related pathways, including cell proliferation, DNA damage response, and apoptosis. We aimed to assess the role of genetic variation in core circadian rhyth...
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Article
Prospective study of effect modification by Toll-like receptor 4 variation on the association between Trichomonas vaginalis serostatus and prostate cancer
In previous studies, we observed a positive association between Trichomonas vaginalis serostatus and risk of prostate cancer, particularly aggressive cancer, which we hypothesized might be due to T. vaginalis-med...
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Article
Seasonal variation in expression of markers in the vitamin D pathway in prostate tissue
Recent studies suggest variation in genes along the vitamin D pathway, as well as vitamin D receptor (VDR) protein levels, may be associated with prostate cancer. As serum vitamin D levels vary by season, we s...
