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Article
Multivitamin use after diagnosis and prostate cancer survival among men with nonmetastatic prostate cancer
Multivitamin use is common among cancer patients. Whether post-diagnostic multivitamin supplementation is beneficial for prostate cancer survival is largely unknown, and some evidence even suggests potential h...
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Article
Protein intake and its association with sleep quality: results from 3 prospective cohort studies
Sleep quality is a critical factor for daytime functioning and chronic disease risk. We investigated the association between intakes of total protein and protein subtypes and sleep quality in three U.S. cohorts.
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Article
The metabolic potential of inflammatory and insulinaemic dietary patterns and risk of type 2 diabetes
Diets with higher inflammatory and insulinaemic potential have been associated with an increased risk of type 2 diabetes. However, it remains unknown whether plasma metabolomic profiles related to proinflammat...
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Article
Different operationalizations of the 2018 WCRF/AICR cancer prevention recommendations and risk of cancer
The standardized scoring system assessing adherence to the 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) cancer prevention recommendations assigns equal weight for each r...
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Article
Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention recommendations throughout the life course and risk of colorectal cancer precursors
Despite the increasing incidence in colorectal cancer (CRC) among the young population, the involvement of modifiable early-life exposures is understudied.
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Article
Open AccessHistopathology images predict multi-omics aberrations and prognoses in colorectal cancer patients
Histopathologic assessment is indispensable for diagnosing colorectal cancer (CRC). However, manual evaluation of the diseased tissues under the microscope cannot reliably inform patient prognosis or genomic v...
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Article
Adolescent dietary patterns in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study
Although adolescent diet has been proposed to contribute to prostate cancer (PCa) development, no studies have investigated the relation between adolescent dietary patterns and PCa risk or mortality.
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Article
Gallstones and risk of cancers of the liver, biliary tract and pancreas: a prospective study within two U.S. cohorts
Gallstones may result in inflammation, altered bile flow, and changes in metabolic hormone levels, thereby increasing cancer risk. However, previous studies for gallstones and cancers of the liver, biliary tra...
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Article
Genetic Obesity Variants and Risk of Conventional Adenomas and Serrated Polyps
Higher body mass index (BMI) is associated with increased risk of colorectal cancer. How genetically predicted BMI may be associated with colorectal cancer precursors is unknown.
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Article
Open AccessPre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear.
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Article
Open AccessSmoking and colorectal cancer survival in relation to tumor LINE-1 methylation levels: a prospective cohort study
Carcinogens in cigarette smoke may cause aberrant epigenomic changes. The hypomethylation of long interspersed nucleotide element-1 (LINE-1) in colorectal carcinoma has been associated with genomic instability...
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Article
Dietary fat and fatty acids in relation to risk of colorectal cancer
Epidemiologic evidence for specific types and sources of dietary fat and individual fatty acid with colorectal cancer (CRC) risk remains inconclusive. We aimed to comprehensively examine the associations of in...
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Article
Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer
Despite heightened interest in early-onset colorectal cancer (CRC) diagnosed before age 50, little is known on immune cell profiles of early-onset CRC. It also remains to be studied whether CRCs diagnosed at o...
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Article
Plasma metabolomic profiles for colorectal cancer precursors in women
How metabolome changes influence the early process of colorectal cancer (CRC) development remains unknown. We conducted a 1:2 matched nested case–control study to examine the associations of pre-diagnostic pla...
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Article
History of Diverticulitis and Risk of Incident Cardiovascular Disease in Men: A Cohort Study
Diverticulitis and cardiovascular disease (CVD) are two highly prevalent disorders sharing common risk factors which are hypothesized to have an inflammatory basis.
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Article
Adolescent animal product intake in relation to later prostate cancer risk and mortality in the NIH-AARP Diet and Health Study
Adolescent intake of animal products has been proposed to contribute to prostate cancer (PCa) development because of its potentially carcinogenic constituents and influence on hormone levels during adolescence.
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Article
Sugar-sweetened beverage, artificially sweetened beverage and sugar intake and colorectal cancer survival
The influence of a high sugar diet on colorectal cancer (CRC) survival is unclear.
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Article
Rising incidence of early-onset colorectal cancer — a call to action
The incidence of early-onset colorectal cancer (CRC), which occurs in individuals <50 years of age, has been increasing worldwide and particularly in high-income countries. The reasons for this increase remain...
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Article
Alcohol intake in early adulthood and risk of colorectal cancer: three large prospective cohort studies of men and women in the United States
Heavy alcohol consumption in mid-adulthood is an established risk factor of colorectal cancer (CRC). Alcohol use in early adulthood is common, but its association with subsequent CRC risk remains largely unkno...
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Article
Open AccessDairy intake during adolescence and risk of colorectal adenoma later in life
Higher dairy intake during adulthood has been associated with lower colorectal cancer risk. As colorectal carcinogenesis spans several decades, we hypothesised that higher dairy intake during adolescence is as...
