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  1. No Access

    Article

    Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy

    Immune checkpoint blockade (ICB) has improved outcomes for patients with advanced cancer, but the determinants of response remain poorly understood. Here we report differential effects of mutations in the homo...

    Robert M. Samstein, Chirag Krishna, **aoxiao Ma, **n Pei, Ken-Wing Lee… in Nature Cancer (2020)

  2. No Access

    Article

    Cancer therapy shapes the fitness landscape of clonal hematopoiesis

    Acquired mutations are pervasive across normal tissues. However, understanding of the processes that drive transformation of certain clones to cancer is limited. Here we study this phenomenon in the context of...

    Kelly L. Bolton, Ryan N. Ptashkin, Teng Gao, Lior Braunstein… in Nature Genetics (2020)

  3. Article

    Open Access

    A machine learning model that classifies breast cancer pathologic complete response on MRI post-neoadjuvant chemotherapy

    For breast cancer patients undergoing neoadjuvant chemotherapy (NAC), pathologic complete response (pCR; no invasive or in situ) cannot be assessed non-invasively so all patients undergo surgery. The aim of ou...

    Elizabeth J. Sutton, Natsuko Onishi, Duc A. Fehr… in Breast Cancer Research (2020)

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