11,809 Result(s)

Article

Correction: Empaglifozin improves kidney senescence induced by d-galactose by reducing sirt1-mediated oxidative stress

Ronghua Fang, Jie Chen, Jiangchuan Long, Binghan Zhang, Qixuan Huang… in Biogerontology (2024)

Article

Correction to: (+)-Catechin Alleviates CCI-Induced Neuropathic Pain in Rats by Modulating the IL34/CSFIR Axis and Attenuating the Schwann Cell-Macrophage Cascade Response in the DRG

Bei **g, Zhen-ni Chen, Wai-mei Si, Jia-ji Zhao, Guo-** Zhao… in Molecular Neurobiology (2024)

Article

MiR-425-5p suppression of Crebzf regulates oocyte aging via chromatin modification

Female infertility due to declining oocyte quality with age remains a significant challenge for patients and physicians, despite extensive research efforts. Recent studies suggest that microRNAs (miRNAs), whic...

Kadiliya Jueraitetibaike, Ting Tang, Rujun Ma, Shanmeizi Zhao, Ronghua Wu… in GeroScience (2024)

Article

Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity

Alzheimer’s disease (AD) is an age-related progressive neurodegenerative disease, and approximately 10% of AD cases are early-onset familial AD (EOFAD), which is mainly linked to point mutations in genes encod...

Chenhao Gao, Junkui Shang, Zhengyu Sun, Mingrong **a, Dandan Gao… in Molecular Neurobiology (2024)

Article

Esketamine Prevents Postoperative Emotional and Cognitive Dysfunction by Suppressing Microglial M1 Polarization and Regulating the BDNF-TrkB Pathway in Ageing Rats with Preoperative Sleep Disturbance

Postoperative depression (POD) and postoperative cognitive dysfunction (POCD) have placed heavy burden on patients’ physical and mental health in recent years. Sleep disturbance before surgery is a common phen...

Yuxin Wen, Jiawen Xu, Jiahong Shen, Zili Tang, Shuxin Li… in Molecular Neurobiology (2024)

Article

Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway

Skin photoaging is mostly caused by ultraviolet A (UVA), although active medications to effectively counteract UVA-induced photoaging have not yet been created. Resveratrol, a naturally occurring polyphenol fo...

Yangmin **a, Hao Zhang, **angyi Wu, Ye Xu, Qian Tan in Biogerontology (2024)

Article

The structural–functional-connectivity coupling of the aging brain

Aging primarily affects memory and executive functions, a relationship that may be underpinned by the fact that almost all adults over 60 years old develop small vessel disease (SVD). The fact that a wide rang...

Hui Zhang, Peng Cao, Henry K. F. Mak, Edward S. Hui in GeroScience (2024)

Article

The Association Between Branched-Chain Amino Acid Concentrations and the Risk of Autism Spectrum Disorder in Preschool-Aged Children

Several studies have linked branched-chain amino acid (BCAA) metabolism disorders with autism spectrum disorder (ASD), but the results have been inconsistent. The purpose of this study was to explore the assoc...

Qi Gao, Dan Bi, Bingbing Li, Min Ni, Dizhou Pang, **an Li… in Molecular Neurobiology (2024)

Article

Single-Cell Transcriptome Reveals Cell Type–Specific Molecular Pathology in a 2VO Cerebral Ischemic Mouse Model

Post-ischemia memory impairment is a major sequela in cerebral ischemia patients. However, cell type–specific molecular pathology in the hippocampus after ischemia is poorly understood. In this study, we adopt...

Qian Zhang, Zhong Xu, Jian-Feng Guo, Shang-Hang Shen in Molecular Neurobiology (2024)

Article

HCMV IE1/IE1mut Therapeutic Vaccine Induces Tumor Regression via Intratumoral Tertiary Lymphoid Structure Formation and Peripheral Immunity Activation in Glioblastoma Multiforme

Glioblastoma multiforme (GBM), a highly malignant invasive brain tumor, is associated with poor prognosis and survival and lacks an effective cure. High expression of the human cytomegalovirus (HCMV) immediate...

**aoli Yang, Shasha Jiang, Fengjun Liu, Zonghui Li, Wenxuan Liu… in Molecular Neurobiology (2024)

Article

Editorial Expression of Concern: Deacetylation of cortactin by SIRT1 promotes cell migration

Y. Zhang, M. Zhang, H. Dong, S. Yong, X. Li, N. Olashaw, P. A. Kruk… in Oncogene (2024)

Article

Correction: HDAC1 Promotes Mitochondrial Pathway Apoptosis and Inhibits the Endoplasmic Reticulum Stress Response in High Glucose-Treated Schwann Cells via Decreased U4 Spliceosomal RNA

Tingting **, Ziming Wang, Fan Fan, Wandi Wei, Chenming Zhou… in Neurochemical Research (2024)

Article

ESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis

Estrogen receptor-positive (ER+) breast cancer accounts for two-thirds of all breast cancers, and its early and late recurrences still threaten patients’ long-term survival and quality of life. Finding candida...

Qing Yu, Chunhua Qu, **liang Liang, Peiqi Chen, Kaiying Zhang… in Clinical Proteomics (2024)

Article

FADD regulates adipose inflammation, adipogenesis, and adipocyte survival

Adipose tissue, aside from adipocytes, comprises various abundant immune cells. The accumulation of low-grade chronic inflammation in adipose tissue serves as a primary cause and hallmark of insulin resistance...

Jianlei Tang, Yue Ma, Meilin Li, **angpeng Liu, Yuting Wang… in Cell Death Discovery (2024)

Article

Correction: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition

Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of the epithelial–mesenchymal transition (EMT) programme. A mesenchymal phenotype predisposes to...

Annemarie Schwab, Zhigang Rao, Jie Zhang, André Gollowitzer… in Nature Cell Biology (2024)

Article

HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage

Drug-induced organic damage encompasses various intricate mechanisms, wherein HMGB1, a non-histone chromosome-binding protein, assumes a significant role as a pivotal hub gene. The regulatory functions of HMGB...

JianYe Yuan, Lin Guo, JiaTing Ma, HeJian Zhang… in Cell Biology and Toxicology (2024)

Article

Retraction Note: LncRNA LINC00337 sponges mir-1285-3p to promote proliferation and metastasis of lung adenocarcinoma cells by upregulating YTHDF1

Ru-nan Zhang, Dong-mei Wu, Li-** Wu, Guo-wei Gao in Cancer Cell International (2024)

Article

IL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages

In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these advances, some patients do not respond well to treatment, highlig...

Jiayu Zhang, Yu Dong, Shan Yu, Keshu Hu, Lingyun Zhang, Min **ong… in Cell Death & Disease (2024)

Article

The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis

Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC). Ubiquitin domain containing 1 (UBTD1), a ubiquitin-like protein, ...

Liqin Zhao, Nuoya Yu, Yujia Zhai, Yanan Yang, Yixuan Wang, Yue Yang… in Cell Death & Disease (2024)