22 Result(s)

Article

Quinolone-induced arthropathy: exposure of magnesium-deficient aged rats or immature rats, mineral concentrations in target tissues and pharmacokinetics

Quinolone treatment or magnesium deficiency induce identical cartilage lesions in juvenile rats and show additive arthropathogenic effects. It has been shown previously that neither condition is arthropathoge...

C. Förster, R. Schwabe, E. Lozo, U. Zippel, J. Vormann… in Archives of Toxicology (1997)

Article

Integrins on joint cartilage chondrocytes and alterations by ofloxacin or magnesium deficiency in immature rats

 Recently, we showed that magnesium deficiency induces lesions in knee joint cartilage from 5-week-old rats that are very similar to ofloxacin-induced cartilage defects. We concluded that quinolone-induced art...

C. Förster, K. Kociok, M. Shakibaei, H.-J. Merker, J. Vormann… in Archives of Toxicology (1996)

Article

Ofloxacin in juvenile non-human primates and rats. Arthropathia and drug plasma concentrations

Arthropathia in juvenile animals is the most important toxic effect induced by quinolones. We conducted pharmacokinetic and morphological studies with ofloxacin on non-human primates (Callithrix jacchus, Marmoset...

R. Stahlmann, H. J. Merker, N. Hinz, I. Chahoud, J. Webb… in Archives of Toxicology (1990)

Article

Influence of 13-cis and all- trans retinoic acid on rat embryonic development in vitro: correlation with isomerisation and drug transfer to the embryo

In vitro experiments using whole rat embryo cultures show that all -trans retinoic acid (all- trans RA) administered at low concentrations (30 ng/ml culture medium) is 10 times more active than 13-cis retinoic ac...

S. Klug, J. Creech Kraft, E. Wildi, H. -J. Merker… in Archives of Toxicology (1989)

Article

An improved method for the preparation of human fetal and adult hepatocytes

A method to prepare isolated hepatocytes from the small amounts of liver or liver fragments obtained from the human fetus following therapeutic abortion in early pregnancy is described. The hepatocytes have be...

C. Liddiard, H.-J. Merker, H. Nau in Archives of Toxicology (1980)

Article

The effect of d-penicillamine of the skeletal development of rat foetuses

Rats received 20, 50 or 100mg/animal d-penicillamine i. p. twice daily on days 15, 16, 17, 18 and 19 of gestation, i. e. a total dose of 200, 500 resp. 1000 mg/animal. At all dosages the number of fetal resorptio...

H. J. Merker, L. Franke, Th. Günther in Naunyn-Schmiedeberg's Archives of Pharmacology (1975)

Article

Benzo(a)pyrene hydroxylase activity in the whole implantation site, decidua, placenta and fetal membranes of the rat

Treatment of pregnant rats with 40 mg benzo(a)pyrene (BP) per kg body weight p.o. 24 h prior to sacrifice results in an induction of BP hydroxylase activity in the whole implantation site, the decidua, the pla...

Eva Schlede, H. -J. Merker in Naunyn-Schmiedeberg's Archives of Pharmacology (1974)

Article

Effect of cyclophosphamide pretreatment of pregnant animals on the activity of nuclear DNA-dependent RNA-polymerases in different parts of rat embryos

On day 13+0 h of gestation rats received 10 mg/kg cyclophosphamide i.p. 3, 9, and 24 h after administration of the drug the activities of the DNA-dependent RNA polymerase reactions were measured in the whole e...

E. Köhler, H.-J. Merker in Naunyn-Schmiedeberg's Archives of Pharmacology (1973)

Article

Growth kinetics of mammalian embryos during the stage of differentiation

In order to get insight into the synthesis rates occuring in mammalian embryos during the phase of differentiation, wet and dry weight as well as DNA-, RNA-, and nitrogen content of the whole implantation site...

E. Köhler, H. -J. Merker, W. Ehmke… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1972)

Article

Effect of benzo(α)pyrene treatment on the benzo(α)pyrene hydroxylase activity in maternal liver, placenta, and fetus of the rat during day 13 to day 18 of gestation

Pregnant rats were treated with an oral dose of 40.0 mg benzo(α) pyrene (BP) per kg body weight and were sacrificed 24 h later. Maternal liver, placenta, and fetus were assayed for BP-hydroxylase activity. The...

Eva Schlede, H.-J. Merker in Naunyn-Schmiedeberg's Archives of Pharmacology (1972)

Article

Studies on the teratogenic phase specificity of actinomycin D in the rat

In order to elucidate the phase specificity of the embryo-lethal and teratogenic action of actinomycin D (day 5–10 of gestation) rats received ³H-actinomycin D at different times of gestation. The distribution of...

E. Köhler, H. -J. Merker in Naunyn-Schmiedeberg's Archives of Pharmacology (1972)

Article

Schädigung und Regeneration renaler Tubuluszellen nach Folsäuregabe

A single intravenous injection of a large dose of folic acid causes an enlargement of the kidneys of rats, which is accompanied by a considerable increase of dry weight. Long lasting functional disturbances of...

W. Brade, H. Herken, H. J. Merker… in Naunyn-Schmiedebergs Archiv für Pharmakolo… (1969)

Article

Elektronenmikroskopische Untersuchungen über den Einfluß von Cyclophosphamid auf die Hirnentwicklung der Ratte

H.-J. Merker, E. Köhler, T. Neuber, S. Spors in Naunyn-Schmiedebergs Archiv für Pharmakolo… (1968)

Article

Biochemical studies on the nucleic acid metabolism of embryonic tissue and the effect of drugs

D. Neubert, E. Oberdisse, H.-J. Merker… in Naunyn-Schmiedebergs Archiv für Pharmakolo… (1968)

Article

Wirkung von Triamteren auf insulinstimulierbare Prozesse des Fettgewebes

1. The effect of triamterene upon glucose uptake and ¹⁴CO₂ production by epididymal adipose tissue of rats was determined in the presence and absence of insulin. Triamterene inhibits insulin dependent glucose upt...

F. von Bruchhausen, H. Herken, H. J. Voss… in Naunyn-Schmiedebergs Archiv für Pharmakolo… (1967)

Article

Änderung der Zellpermeabilität durch Cortison und Dexamethason

Sodium (distribution) space and sucrose space of liver and muscle were measured in vivo in rats following the application of cortisone and dexamethasone.

C. Goecke, Th. Günther, H. J. Dulce… in Naunyn-Schmiedebergs Archiv für Pharmakolo… (1967)

Article

Untersuchungen an der isolierten Basalmembran der Niere

F. v. Bruchhausen, H. J. Merker in Naunyn-Schmiedebergs Archiv für experiment… (1965)

Article

Gewinnung und morphologische Charakterisierung einer Basalmembranfraktion aus der Nierenrinde der Ratte

1. Aus der sogenannten Kernfraktion von Rattennierenrinden-Homogenaten lassen sich durch nicht-kontinuierliche oder Schichten gradienten-Zentrifugation in Saccharose Basalmembranen anreichern.

F. v. Bruchhausen, H. J. Merker in Naunyn-Schmiedebergs Archiv für experiment… (1965)

Article

Vermehrung arzneimitteloxydierender Enzyme durch Tolbutamid

Tolbutamid stimuliert die Oxydation von Hexobarbital mit Hilfe mikrosomaler Leberenzyme bei Ratte, Kaninchen und Hund, wodurch die Wirkungsdauer bis auf ein Fünftel der Norm absinkt. Sulfaethidol und Sulfanila...

H. Remmer, M. Siegert, H. J. Merker in Naunyn-Schmiedebergs Archiv für experiment… (1964)

Article

Struktur und Funktion der Glomerula nach Einwirkung von Glucocorticoiden bei der Aminonucleosidnephrose

H. Herken, G. Senft, W. Schwarz… in Naunyn-Schmiedebergs Archiv für experiment… (1963)