1,347 Result(s)
within
English
Chemistry
Biotechnology
Guo Si**
Article
-
Article
Activation of MAL2 by RAD21 inhibits the expression of MHC-I in immune evasion of endometrial cancer
CD8+ T cells are the primary mediators of anticancer immunity, and modulation of the CD8+ T cell response has been a central focus of immunotherapy to treat cancer. When CD8+ T cells specifically recognize antige...
-
Article
Research Progress on Gas Generation from Waste Plastics Through Pyrolysis
Plastic pyrolysis technology, as an efficient and stable path for chemical recycling of waste plastics, alleviates current energy pressures and solves the problem of continuous accumulation of waste plastics i...
-
Article
Open AccessInjective hydrogel loaded with liposomes-encapsulated MY-1 promotes wound healing and increases tensile strength by accelerating fibroblast migration via the PI3K/AKT-Rac1 signaling pathway
Failed skin wound healing, through delayed wound healing or wound dehiscence, is a global public health issue that imposes significant burdens on individuals and society. Although the application of growth fac...
-
Article
Open AccessTargeted delivery of CEBPA-saRNA for the treatment of pancreatic ductal adenocarcinoma by transferrin receptor aptamer decorated tetrahedral framework nucleic acid
Pancreatic cancer, predominantly pancreatic ductal adenocarcinoma (PDAC), remains a highly lethal malignancy with limited therapeutic options and a dismal prognosis. By targeting the underlying molecular abnor...
-
Article
Theoretically and Experimentally Exploring the Inhibition Effect of Imidazole Sulfonic Acid Derivatives with Multiple Adsorption Sites in 1.0 mol/L HCl
Corrosion inhibitors have played a huge role in daily life and industrial production. Imidazole and sulfonic acid groups have high corrosion inhibition capabilities. To further improve their excellent corrosio...
-
Article
Open AccessTargeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury
Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to the myocardium. This phenomenon is known as myocardi...
-
Article
3D Bioprinting of Cultured Meat: A Promising Avenue of Meat Production
Cultured meat is considered to be a viable alternative to conventional flesh to satisfy the increasing human demand for meat. However, current cultured meat products fail to meet consumer expectations. This pa...
-
Article
Open AccessHigh-temperature PTT/CDT coordination nanoplatform realizing exacerbated hypoxia for enhancing hypoxia-activated chemotherapy to overcome tumor drug resistance
Hypoxia-activated prodrugs present new opportunities for safe and effective tumor drug resistance therapy due to their high selectivity for hypoxic cells. However, the uneven distribution of oxygen in solid tu...
-
Article
Open AccessDe novo biosynthesis of β-arbutin in Corynebacterium glutamicum via pathway engineering and process optimization
β-Arbutin, a hydroquinone glucoside found in pears, bearberry leaves, and various plants, exhibits antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. β-Arbutin has wide applications in the ...
-
Article
Open AccessPotentiating dual-directional immunometabolic regulation with nanomedicine to enhance anti-tumor immunotherapy following incomplete photothermal ablation
Photothermal therapy (PTT) is a promising cancer treatment method due to its ability to induce tumor-specific T cell responses and enhance therapeutic outcomes. However, incomplete PTT can leave residual tumor...
-
Article
Open AccessCold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure...
-
Article
Open AccessCargo-eliminated osteosarcoma-derived small extracellular vesicles mediating competitive cellular uptake for inhibiting pulmonary metastasis of osteosarcoma
Osteosarcoma (OS) derived small extracellular vesicles (OS-sEVs) have been shown to induce the formation of cancer-associated fibroblasts (CAFs), characterized by elevated pro-inflammatory factor expression an...
-
Article
Open AccessNIR-responsive CN-Pt-GEM hydrogel induces necroptosis and immunotherapeutic responses prevent postoperative recurrence and wound infection in lung carcinoma
Cancer recurrence following surgical resection is a major cause of treatment failure. Finding effective methods to prevent postoperative recurrence and wound infection is an important component of successful s...
-
Article
Soil Organic Matter and Total Nitrogen Reshaped Root-Associated Bacteria Community and Synergistic Change the Stress Resistance of Codonopsis pilosula
The stress resistance of medicinal plants is essential to the accumulation of pharmacological active ingredients, but the regulation mechanism of biological factors and abiotic factors on medicinal plants is s...
-
Article
Open AccessTargeting SUMOylation with an injectable nanocomposite hydrogel to optimize radiofrequency ablation therapy for hepatocellular carcinoma
Incomplete radiofrequency ablation (iRFA) in hepatocellular carcinoma (HCC) often leads to local recurrence and distant metastasis of the residual tumor. This is closely linked to the development of a tumor im...
-
Article
Solvent-Free Enzymatic Synthesis of Ethyl 3-Oxobutyrate Derivative: Characterization and Optimization of Reaction Condition
It was first found that porcine pancreatic lipase (PPL) could catalyze the Knoevenagel condensation of aromatic aldehydes and ethyl acetoacetate under solvent-free conditions in this paper. Under solvent-free ...
-
Article
The aging and color development of writing in paper archives
The most important value of archives lies in the handwritten information they record. However, during the storage process, handwriting may change color or fade due to the influence of the storage environment, ...
-
Article
Effects of Penetrating Microwave Blanching on the Drying Characteristics, Physicochemical Properties, and Water Migration of Pleurotus eryngii: Observation of Cell Wall Polysaccharides and Microstructure
This study introduces a novel penetrating microwave infrared hot-air rolling-bed dryer for blanching and drying Pleurotus eryngii. We investigated the effects of different penetrating microwave blanching times (0...
-
Article
The Effect of Thermosonication Treatment on the Inactivation of Clostridium perfringens Spores
Clostridium perfringens spores, which are extremely resistant and difficult to kill, can easily cause food spoilage and foodborne diseases. In this study, the effect of simultaneous ultrasound and heat (thermoso...
-
Article
Open AccessEpithelium-derived exosomes promote silica nanoparticles-induced pulmonary fibroblast activation and collagen deposition via modulating fibrotic signaling pathways and their epigenetic regulations
In the context of increasing exposure to silica nanoparticles (SiNPs) and ensuing respiratory health risks, emerging evidence has suggested that SiNPs can cause a series of pathological lung injuries, includin...
