19 Result(s)
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Article
Allard C. van der Wal
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Open AccessHigh-risk coronary plaque of sudden cardiac death victims: postmortem CT angiographic features and histopathologic findings
High-risk coronary plaques (HRP) are characterized in clinical radiological imaging by the presence of low plaque attenuation, a napkin-ring sign (NRS), spotty calcifications (SC) and a positive remodeling ind...
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Open AccessCoronary CT angiography for the assessment of atherosclerotic plaque inflammation: postmortem proof of concept with histological validation
To evaluate the diagnostic utility of multiphase postmortem CT angiography (PMCTA) to detect plaque enhancement as a surrogate marker of inflammation, using fatal coronary plaques obtained from autopsies follo...
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Open AccessGenetically determined cardiomyopathies at autopsy: the pivotal role of the pathologist in establishing the diagnosis and guiding family screening
Cardiomyopathies (CMP) comprise a heterogenous group of diseases affecting primarily the myocardium, either genetic and/or acquired in origin. While many classification systems have been proposed in the clinic...
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Open AccessApplication of postmortem imaging modalities in cases of sudden death due to cardiovascular diseases–current achievements and limitations from a pathology perspective
Postmortem imaging (PMI) is increasingly used in postmortem practice and is considered a potential alternative to a conventional autopsy, particularly in case of sudden cardiac deaths (SCD). In 2017, the Assoc...
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Correction to: Cardiac hypertrophy at autopsy
A correction to this paper has been published: https://doi.org/10.1007/s00428-021-03118-1
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An updated approach to sudden cardiac death, the AECVP perspective
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Open AccessCardiac hypertrophy at autopsy
Since cardiac hypertrophy may be considered a cause of death at autopsy, its assessment requires a uniform approach. Common terminology and methodology to measure the heart weight, size, and thickness as well ...
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Open AccessAutopsy in adults with congenital heart disease (ACHD)
The adult congenital heart diseases (ACHD) population is exceeding the pediatric congenital heart diseases (CHD) population and is progressively expanding each year, representing more than 90% of patients with...
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Open AccessDiagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification
Ischemic heart disease is one of the leading causes of morbidity and death worldwide. Consequently, myocardial infarctions are often encountered in clinical and forensic autopsies, and diagnosis can be challen...
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Open AccessPatched-2 functions to limit Patched-1 deficient skin cancer growth
Basal cell carcinoma (BCC) is one of the most common skin cancers, and is typically driven by an aberrantly activated Hedgehog (Hh) pathway. The Hh pathway is regulated by interactions between the Patched-1 (P...
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Sudden aortic death—proposal for a comprehensive diagnostic approach in forensic and in clinical pathology practice
Aortic rupture or dissection as immediate cause of sudden death is encountered in forensic and clinical autopsy practice. Despite a common denominator of ‘sudden aortic death’ (SAD), we expect that in both set...
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Open AccessLymph vessels: the forgotten second circulation in health and disease
The lymphatic circulation is still a somewhat forgotten part of the circulatory system. Despite this, novel insights in lymph angiogenesis in health and disease, application of immune markers for lymphatic gro...
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Total burden of intraplaque hemorrhage in coronary arteries relates to the use of coumarin-type anticoagulants but not platelet aggregation inhibitors
Intraplaque hemorrhage (IPH) is a crucial factor in progression and destabilization of an atherosclerotic plaque. Anti-thromboembolic drugs are widely used as prophylactic treatment against arterial and venous...
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Coronary cardiac allograft vasculopathy versus native atherosclerosis: difficulties in classification
Cardiac allograft vasculopathy is regarded as a progressive and diffuse intimal hyperplastic lesion of arteries and veins that leads to insidious vessel narrowing and to allograft ischemic disease, such as acu...
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Open AccessReduction of Cardiac Cell Death after Helium Postconditioning in Rats: Transcriptional Analysis of Cell Death and Survival Pathways
Helium, a noble gas, has been used safely in humans. In animal models of regional myocardial ischemia/reperfusion (I/R) it was shown that helium conditioning reduces infarct size. Currently, it is not known ho...
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Open AccessOptimization of Suture-Free Laser-Assisted Vessel Repair by Solder-Doped Electrospun Poly(ε-caprolactone) Scaffold
Poor welding strength constitutes an obstacle in the clinical employment of laser-assisted vascular repair (LAVR) and anastomosis. We therefore investigated the feasibility of using electrospun poly(ε-caprolac...
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Open AccessTwo Cases of Cardiac Arteriovenous Malformation Complicated by a Local Angioproliferative Process
Vascular malformations of the heart are extremely rare with only a few cases of the arteriovenous type of vascular malformation (AVM) reported. We investigated the pathology of two additional cases, which were...
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Metallothionein in human atherosclerotic lesions: a scavenger mechanism for reactive oxygen species in the plaque?
Oxidative stress is important in the genesis of atherosclerotic lesions. The extracellular effects of reactive oxygen species (ROS), such as oxidative modification of lipoproteins and upregulation of matrix d...
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Morphologic and functional consequences of intimal hyperplasia in the rat carotid artery
The influence of neointima formation on functional characteristics was investigated in rat carotid artery preparations. The process of intimal hyperplasia development in the injured carotid arteries was follo...
