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Article
Open AccessSubject-specific finite element head models for skull fracture evaluation—a new tool in forensic pathology
Post-mortem computed tomography (PMCT) enables the creation of subject-specific 3D head models suitable for quantitative analysis such as finite element analysis (FEA). FEA of proposed traumatic events is an o...
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Article
Open AccessPrediction of skull fractures in blunt force head traumas using finite element head models
Traumatic head injuries remain a leading cause of death and disability worldwide. Although skull fractures are one of the most common head injuries, the fundamental mechanics of cranial bone and its impact tol...
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Article
Open Access3D printed skulls in court — a benefit to stakeholders?
Forensic pathologists may use 3D prints as demonstrative aids when providing expert testimony in court of law, but the effects remain unclear despite many assumed benefits. In this qualitative study, the effec...
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Article
The intracranial pressure–volume relationship following decompressive hinge craniotomy compared to decompressive craniectomy—a human cadaver study
Decompressive hinge craniotomy (DHC) is an alternative treatment option to decompressive craniectomy (DC) for elevated intracranial pressure (ICP). The aim of this study was to characterize the difference in p...
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Article
Open AccessApplication of postmortem imaging modalities in cases of sudden death due to cardiovascular diseases–current achievements and limitations from a pathology perspective
Postmortem imaging (PMI) is increasingly used in postmortem practice and is considered a potential alternative to a conventional autopsy, particularly in case of sudden cardiac deaths (SCD). In 2017, the Assoc...
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Article
Sensitivity and specificity of post-mortem computed tomography in skull fracture detection—a systematic review and meta-analysis
Post-mortem computed tomography (PMCT) has been increasingly used as routine examination in forensic pathology. No recent review of the growing number of papers on the ability of PMCT to detect skull fracture ...
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Article
Fractures of the neuro-cranium: sensitivity and specificity of post-mortem computed tomography compared with autopsy
Post–mortem computed tomography (PMCT) is a routine tool in many forensic pathology departments as it is fast and non-destructive and allows less gruesome visualization than photographs, and the images are ind...
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Article
Open AccessEpidemiologie und Therapie der behandlungsbedürftigen Frühgeborenenretinopathie. Die Hannoveraner Daten im Retina.net ROP-Register von 2001 bis 2017
Das Retina.net ROP-Register erhebt Daten von Kindern, die eine seltene behandlungsbedürftige Frühgeborenenretinopathie (Retinopathy of Prematurity, ROP) entwickeln. Ziel dieser Auswertung ist die Untersuchung der...
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Article
Open AccessSelective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results
Central serous chorioretinopathy (CSC) is a disease presenting with detachment of the neurosensory retina and characteristic focal leakage on fluorescein angiography. The spontaneous remission rate is 84% with...
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Article
Comparison of hippocampal volume measurement by autopsy and post-mortem magnetic resonance imaging
We present an autopsy-validated, non-invasive, magnetic resonance imaging (MRI) based segmentation algorithm, for determining hippocampal volume. A segmentation algorithm was developed to assess the volume of ...
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Article
Coronary artery CT calcium score assessed by direct calcium quantification using atomic absorption spectroscopy and compared to macroscopic and histological assessments
The Agatston score (AS) is the gold standard CT calcium scoring method in clinical practice. However, the AS is an indirect method of determining calcium amount, whereas atomic absorption spectroscopy (AAS) ca...
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Article
Retinoic-acid-induced osteogenesis of hiPSCs
Retinoic acid induces the rapid osteogenic differentiation of patient-derived induced pluripotent stem cells, enabling the in vitro recapitulation of an osteogenesis imperfecta phenotype.
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Article
Open AccessCardiac left ventricular myocardial tissue density, evaluated by computed tomography and autopsy
Left ventricular mass (LVM) is an independent risk factor for the prediction of cardiac events. Its assessment is a clinically important diagnostic procedure in cardiology and may be performed by Computed Tomo...
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The Application of Photogrammetry for Forensic 3D Recording of Crime Scenes, Evidence and People
Recently, new forms of documentation such as photogrammetry are increasingly used in forensic sciences. Photogrammetry enables an actual 3D recording of crime scenes. This technique can be used to extract 3D m...
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Article
The accessory magnocellular neurosecretory system of the rostral human hypothalamus
The morphology and neurophysin expression of the magnocellular accessory neuroendocrine system located in the rostral human hypothalamus is investigated in a series of brains obtained at autopsy. The hypothala...
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Article
Epicardial adipose tissue volume estimation by postmortem computed tomography of eviscerated hearts
Epicardial adipose tissue (EAT) may play a role in the development of coronary artery disease. The purpose of this study was to evaluate a method based on postmortem computed tomography (PMCT) for the estimati...
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Article
Correction: Corrigendum: SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome
Nat. Genet. 49, 238–248 (2017); published online 9 January 2017; corrected after print 20 March 2017 In the version of this article initially published, the legend to Figure 4c stated that only one proband wit...
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Article
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome
Michael Talkowski, David FitzPatrick, Erica Davis and colleagues report rare inherited or de novo missense variants in SMCHD1 in arhinia patients. Some of the same mutations in SMCHD1 are known to cause a phenoty...
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Article
Forensic postmortem computed tomography: volumetric measurement of the heart and liver
The purpose of this study was to investigate the utility of postmortem computed tomography (PMCT) images in estimating organ sizes and to examine the use of the cardiothoracic ratio (CTR).
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Article
Open AccessA comparative study of cranial, blunt trauma fractures as seen at medicolegal autopsy and by Computed Tomography
Computed Tomography (CT) has become a widely used supplement to medico legal autopsies at several forensic institutes. Amongst other things, it has proven to be very valuable in visualising fractures of the cr...
