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Article
Open AccessChronic liver disease and hepatic calcium-oxalate deposition in patients with primary hyperoxaluria type I
Patients with primary hyperoxaluria type I (PH I) are prone to develop early kidney failure. Systemic deposition of calcium-oxalate (CaOx) crystals starts, when renal function declines and plasma oxalate incre...
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Article
Open AccessOrgan manifestations of COVID-19: what have we learned so far (not only) from autopsies?
The use of autopsies in medicine has been declining. The COVID-19 pandemic has documented and rejuvenated the importance of autopsies as a tool of modern medicine. In this review, we discuss the various autops...
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Article
Open AccessCase report: a peculiar glomerulopathy in a patient suffering from nephrotic syndrome
Podocyte infolding glomerulopathy (PIG) is a rare histopathologic finding with global infolding of the podocytes into the glomerular basement membrane (GBM), accompanied by microstructures underneath. Describe...
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Article
Open AccessElevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma
Molecular markers predicting survival in esophageal adenocarcinoma (EAC) are rare. Specifically, in favorable oncologic situations, e.g. nodal negativity or major neoadjuvant therapy response, there is a lack ...
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Article
Open AccessTumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer
Immune infiltration is implicated in the development of acquired resistance to anti-angiogenic cancer therapy. We therefore investigated the correlation between neutrophil infiltration in metastasis of colorec...
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Article
Open AccessTargeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus
Ciliopathies comprise a large number of hereditary human diseases and syndromes caused by mutations resulting in dysfunction of either primary or motile cilia. Both types of cilia share a similar architecture....
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Article
Open AccessCharacterization of a splice-site mutation in the tumor suppressor gene FLCN associated with renal cancer
Renal cell carcinoma is among the most prevalent malignancies. It is generally sporadic. However, genetic studies of rare familial forms have led to the identification of mutations in causative genes such as VHL ...
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Article
Open AccessCilia-associated cellular function of the AAA ATPases RUVBL1 and RUVBL2
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Article
Conditional loss of kidney microRNAs results in congenital anomalies of the kidney and urinary tract (CAKUT)
MicroRNAs have emerged as essential regulators of gene expression and may play important roles in a variety of human disorders. To understand the role of microRNA-mediated gene regulation in the kidney, we del...
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Article
Anatomical refixation for acute ruptures of the distal biceps tendon using a novel transcortical refixation system
In this study, minimally invasive CurvTek refixation is introduced as a novel approach for repair of distal biceps tendon ruptures. Exploration at the radial tuberosity is minimized using CurvTek, thereby redu...
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Article
Congenital left ventricular apical aneurysm or diverticulum mimicking infarct aneurysm and a right ventricular diverticulum in an adult
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Article
Uterosacral ligament in postmenopausal women with or without pelvic organ prolapse
The uterosacral ligaments are thought to contribute to pelvic support. The objective of this study was to compare the structural components of these ligaments in women with and without pelvic organ prolapse (P...
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Article
Discrepancy between GLUT4 translocation and glucose uptake after ischemia
Objective: Low-flow ischemia results in glucose transporter translocation and in increased glucose uptake. After total ischemia in rat heart, we found no increase in glucose uptake. Here we test the hypothesis th...
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Article
Metallothionein in human atherosclerotic lesions: a scavenger mechanism for reactive oxygen species in the plaque?
Oxidative stress is important in the genesis of atherosclerotic lesions. The extracellular effects of reactive oxygen species (ROS), such as oxidative modification of lipoproteins and upregulation of matrix d...
