61 Result(s)

Article

Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity

The secretion of synaptic and other vesicles is a complex process involving multiple steps. Many molecular components of the secretory apparatus have been identified, but how they relate to the different stage...

Tao Xu, Thomas Binz, Heiner Niemann, Erwin Neher in Nature Neuroscience (1998)

Article

Visual input induces long-term potentiation of develo** retinotectal synapses

Early visual experience is essential in the refinement of develo** neural connections. In vivo whole-cell recording from the tectum of Xenopus tadpoles showed that repetitive dimming-light stimulation applied t...

Li I. Zhang, Hui-zhong W. Tao, Mu-ming Poo in Nature Neuroscience (2000)

Article

Probing ion permeation and gating in a K⁺ channel with backbone mutations in the selectivity filter

Potassium channels selectively conduct K⁺ ions across cell membranes, and use diverse mechanisms to control their gating. We studied ion permeation and gating of an inwardly rectifying K⁺ channel by individually ...

Tao Lu, Alice Y. Ting, Joel Mainland, Lily Y. Jan, Peter G. Schultz… in Nature Neuroscience (2001)

Article

Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons

Migration of neuronal precursor cells from the external germinal layer (EGL) to the internal granular layer (IGL) is a crucial process in the development of the mammalian cerebellar cortex. These cells make up...

Yan Zhu, Tao Yu, **ao-Chun Zhang, Takashi Nagasawa, Jane Y. Wu… in Nature Neuroscience (2002)

Article

Differential regulation of synaptic and extra-synaptic NMDA receptors

A variety of processes limit NMDA (N-methyl-D-aspartate) receptor (NMDAR) activity in response to agonist exposure, including rundown—the decline of peak current with repeated, sustained agonist application^1,2,3,

Bo Li, Nansheng Chen, Tao Luo, Yo Otsu, Timothy H. Murphy… in Nature Neuroscience (2002)

Article

Molecular approaches to brain asymmetry and handedness

Article

The virtue of simplicity

Multiple local motions must be combined to determine the direction of object motion, which is harder than it seems. A new paper proposes an elegant and simple solution to this problem, eminently realizable in ...

Tao Zhang, Kenneth H Britten in Nature Neuroscience (2006)

Article

Defining cortical frequency tuning with recurrent excitatory circuitry

Neurons in the recipient layers of sensory cortices receive excitatory input from two major sources: the feedforward thalamocortical and recurrent intracortical inputs. To address their respective functional r...

Bao-hua Liu, Guangying K Wu, Robert Arbuckle, Huizhong W Tao… in Nature Neuroscience (2007)

Article

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

Here, Tain et al. describe the genetic interaction between 4E-BP, an inhibitor of translation, with Parkinson's disease–associated park and Pink1 in Drosophila, where the manipulation of 4E-BP reduced the patholo...

Luke S Tain, Heather Mortiboys, Ran N Tao, Elena Ziviani… in Nature Neuroscience (2009)

Article

Intervening inhibition underlies simple-cell receptive field structure in visual cortex

Simple cell receptive fields (RFs) consist of spatially segregated 'On' and 'Off' subregions. Previous work suggested that excitatory inputs underlie this segregation. This study uses voltage clamp recordings ...

Bao-hua Liu, **yang Li, Yujiao J Sun, Ya-tang Li, Li I Zhang… in Nature Neuroscience (2010)

Article

CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis

Cuprizone causes demyelination and oligodendrocyte death in mice. Cuprizone lesions resemble a particular form of white-matter lesions that is seen in multiple sclerosis. This study reports that infiltrating n...

Li** Liu, Abdelmadjid Belkadi, Lindsey Darnall, Taofang Hu… in Nature Neuroscience (2010)

Article

C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog

The mechanism of light sensation in the worm C. elegans has been unclear. Liu and colleagues describe a G protein–dependent signaling cascade for light transduction that is similar to the mechanism for taste sens...

Jie Liu, Alex Ward, **gwei Gao, Yongming Dong, Nana Nishio… in Nature Neuroscience (2010)

Article

Calcium-channel number critically influences synaptic strength and plasticity at the active zone

This study uses single-channel current measurements, synaptic vesicle fusion–induced capacitance changes and structural modeling of the calyx of Held terminals to show that voltage-dependent calcium channel de...

Jiansong Sheng, Liming He, Hongwei Zheng, Lei Xue, Fujun Luo… in Nature Neuroscience (2012)

Article

Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons

This study describes the synaptogenic function of an ErbB2-interacting protein called Erbin, particularly its function in the formation of excitatory synapses on interneurons and its regulation of AMPA-type gl...

Yanmei Tao, Yong-Jun Chen, Chengyong Shen, Zhengyi Luo, C Ryan Bates… in Nature Neuroscience (2013)

Article

A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons

Zhao and colleagues find that neuropathic pain is accompanied by an increase in the expression of an antisense long noncoding RNA (lncRNA) that downregulates Kcna2 currents and increases excitability in rat do...

**uli Zhao, Zongxiang Tang, Hongkang Zhang, Fidelis E Atianjoh… in Nature Neuroscience (2013)

Article

Intracortical multiplication of thalamocortical signals in mouse auditory cortex

How the cortex processes and transforms sensory input coming from the thalamus is still a matter of debate. Here the authors optogenetically silence local cortical circuits to show that intracortical excitatio...

Ling-yun Li, Ya-tang Li, Mu Zhou, Huizhong W Tao, Li I Zhang in Nature Neuroscience (2013)

Article

Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits

Phosphorylation of the eukaryotic initiation factor 2 α subunit (eIF2α) is increased in the brains of Alzheimer's disease patients and model mice. Here the authors show that knocking down two kinases that phos...

Tao Ma, Mimi A Trinh, Alyse J Wexler, Clarisse Bourbon… in Nature Neuroscience (2013)

Article

Linear transformation of thalamocortical input by intracortical excitation

By silencing intracortical excitation in mouse primary visual cortex, Li and colleagues find that the tuning of layer 4 pyramidal cells is independent of cortico-cortical inputs. Instead, intracortical excitat...

Ya-tang Li, Leena A Ibrahim, Bao-hua Liu, Li I Zhang… in Nature Neuroscience (2013)

Article

Unbalanced excitability underlies offline reactivation of behaviorally activated neurons

The authors show that sharp-wave events recorded in mouse hippocampal slices are more likely to involve neurons that have been activated during a recent behavioral episode. The excitation/inhibition balance of...

Mika Mizunuma, Hiroaki Norimoto, Kentaro Tao, Takahiro Egawa… in Nature Neuroscience (2014)