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Article
Identification and validation of major and stable quantitative trait locus for falling number in common wheat (Triticum aestivum L.)
A major and stable QTL, QFn.sau-1B.2, which can explain 13.6% of the PVE in FN and has a positive effect on resistance in SGR, was mapped and validated.
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Article
Open AccessThe different subtelomeric structure among 1RS arms in wheat-rye 1BL.1RS translocations affecting their meiotic recombination and inducing their structural variation
The 1RS arm of wheat-rye 1BL.1RS translocations contains several subtelomeric tandem repeat families. To study the effect of the difference in the composition of these tandem repeats on the meiotic recombinati...
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Article
Open AccessUpregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction
Metabolic dysregulations have emerged as a major mediator of cardiovascular disorders and fibrotic diseases. Metabolic reprogramming contributes a lot to cardiac fibroblast activation and cardiac fibrosis post...
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Article
Rutin ameliorates inflammatory pain by inhibiting P2X7 receptor in mast cells
Rutin is a natural anti-inflammatory ingredient widely found in medicinal plants. Studies have shown that rutin inhibits mast cell degranulation and the release of inflammatory mediators. Mast cell P2X7 recept...
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Article
Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor
Curcumin is a diketone compound extracted from the rhizomes of some plants in the Zingiberaceae and Araceae family. It possesses a variety of biological activities, including antioxidant, anti-inflammatory and...
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Article
Mast cell stabilization: new mechanism underlying the therapeutic effect of intense pulsed light on rosacea
Rosacea, a chronic inflammatory disorder of the facial skin, is effectively treated by intense pulsed light (IPL).
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Article
Chromosomes polymorphisms of Sichuan wheat cultivars displayed by ND-FISH landmarks
Although fluorescence in situ hybridization (FISH) karyotypes of wheat chromosomes have already been widely investigated, more probes are needed to enrich them. Novel karyotype characteristics of 166 common wh...
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Article
Open AccessVariations of subtelomeric tandem repeats and rDNA on chromosome 1RS arms in the genus Secale and 1BL.1RS translocations
The wheat-rye 1BL.1RS translocations have played an important role in common wheat breeding programs. Subtelomeric tandem repeats have been often used to investigate polymorphisms of 1RS arms, but further rese...
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Article
Mechanically evoked defensive attack is controlled by GABAergic neurons in the anterior hypothalamic nucleus
Innate defensive behaviors triggered by environmental threats are important for animal survival. Among these behaviors, defensive attack toward threatening stimuli (for example, predators) is often the last li...
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Article
Open AccessAssessing the post-treatment therapeutic effect of pinaverium in irritable bowel syndrome: a randomized controlled trial
Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder significantly decreasing patients’ lives of quality and placing huge economic burden on our society. Existing studies indicated that ...
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Article
Open AccessFISH landmarks reflecting meiotic recombination and structural alterations of chromosomes in wheat (Triticum aestivum L.)
DNA sequence composition affects meiotic recombination. However, the correlation between tandem repeat composition and meiotic recombination in common wheat (Triticum aestivum L.) is unclear.
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Article
Characterization of a new gene for resistance to wheat powdery mildew on chromosome 1RL of wild rye Secale sylvestre
PmSESY, a new wheat powdery mildew resistance gene was characterized and genetically mapped to the terminal region of chromosome 1RL of wild rye Secale sylvestre.
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Article
Open AccessMolecular dissection of Secale africanum chromosome 6Rafr in wheat enabled localization of genes for resistance to powdery mildew and stripe rust
Introgression of chromatin from Secale species into common wheat has for decades been a successful strategy for controlling the wheat diseases. The wild Secale species, Secale africanum Stapf., is a valuable sour...
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Article
Open AccessExpression and localization of MrgprD in mouse intestinal tract
MrgprD, a Mas-related G protein-coupled receptor, is initially identified in sensory neurons of mouse dorsal root ganglia (DRG) and has been suggested to participate in somatosensation. However, MrgprD has rec...
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Article
Physical location of tandem repeats in the wheat genome and application for chromosome identification
A general distribution of tandem repeats (TRs) in the wheat genome was predicted and a new web page combined with fluorescence in situ hybridization experiments, and the newly developed Oligo p...
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Article
Stable expression and heredity of alien Glu-1Ssh in wheat-Aegilops sharonensis hybrid progenies
In our previous study, we have isolated novel HMW-GSs with unusually large molecular weight from Aegilops sharonensis; and to introduce this novel HMW-GSs variant into common wheat, we produced a number of amphip...
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Article
Open AccessThe genome-wide transcriptional consequences of the nullisomic-tetrasomic stocks for homoeologous group 7 in bread wheat
Hexaploid bread wheat (Triticum aestivum L) arose by two polyploidisation events from three diploid species with homoeologous genomes. Nullisomic-tetrasomic (nulli-tetra or NT) lines are aneuploid wheat plants la...
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Article
Open AccessAn effective and concise device for detecting cold allodynia in mice
Detection of cold allodynia is a very important aspect in the study of pain behavior. An effective and concise device for detecting cold pain has always been the hope of many researchers. Here, an easily produ...
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Article
Open AccessMatrine inhibits itching by lowering the activity of calcium channel
Sophorae Flavescentis Radix (SFR) is a medicinal herb with many functions that are involved in anti-inflammation, antinociception, and anticancer. SFR is also used to treat a variety of itching diseases. Matrine ...
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Article
Novel source of 1RS from Baili rye conferred high resistance to diseases and enhanced yield traits to common wheat
Rye is one of the most important related species used for wheat genetic improvement and breeding programs. In the present study, five novel 1BL.1RS translocations were developed and characterized from crossing...
