240 Result(s)
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Article
Open AccessCellular miR-130b inhibits replication of porcine reproductive and respiratory syndrome virus in vitro and in vivo
MicroRNAs (miRNAs) can impact viral infections by binding to sequences with partial complementarity on viral RNA transcripts, usually resulting in the repression of virus replication. In the present study, we ...
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Open AccessGlobal Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network
The identification of disease-related metabolites is important for a better understanding of metabolite pathological processes in order to improve human medicine. Metabolites, which are the terminal products o...
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Open AccessThe fish diversity in the upper reaches of the Salween River, Nujiang River, revealed by DNA barcoding
Nujiang River (NR), an essential component of the biodiversity hotspot of the Mountains of Southwest China, possesses a characteristic fish fauna and contains endemic species. Although previous studies on fish...
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Open AccessCellMethy: Identification of a focal concordantly methylated pattern of CpGs revealed wide differences between normal and cancer tissues
DNA methylation patterns may serve as a key in determining cell phenotypes and functions. Adjacent CpG patterns may provide insight into methylation functional mechanisms. Some regions display different DNA me...
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Open AccessThe identification of age-associated cancer markers by an integrative analysis of dynamic DNA methylation changes
As one of the most widely studied epigenetic modifications, DNA methylation has an important influence on human traits and cancers. Dynamic variations in DNA methylation have been reported in malignant neoplas...
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Open AccessThe effect of positioning cations on acidity and stability of the framework structure of Y zeolite
The investigation on the modification of NaY zeolite on LaHY and AEHY (AE refers Ca and Sr and the molar ratio of Ca and Sr is 1:1) zeolites was proformed by XRD, N2-physisorption (BET), XRF, XPS, NH3-TPD, Py-IR,...
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Open AccessLandscape of genomic diversity and trait discovery in soybean
Cultivated soybean [Glycine max (L.) Merr.] is a primary source of vegetable oil and protein. We report a landscape analysis of genome-wide genetic variation and an association study of major domestication and ag...
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Open AccessPossible association of CCDC62 rs12817488 polymorphism and Parkinson’s disease risk in Chinese population: a meta-analysis
Conflicting results identifying the association between coiled-coil domain containing 62 (CCDC62) polymorphism, rs12817488 and Parkinson’s disease (PD) have been reported. To clarify whether rs12817488 is rela...
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Open AccessPotential use of bacterial community succession for estimating post-mortem interval as revealed by high-throughput sequencing
Decomposition is a complex process involving the interaction of both biotic and abiotic factors. Microbes play a critical role in the process of carrion decomposition. In this study, we analysed bacterial comm...
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Open AccessIndian monsoon variability on millennial-orbital timescales
The Indian summer monsoon (ISM) monsoon is critical to billions of people living in the region. Yet, significant debates remain on primary ISM drivers on millennial-orbital timescales. Here, we use speleothem ...
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Open AccessAssociations of Exhaled Carbon Monoxide and Fractional Exhaled Nitric Oxide with Metabolic Syndrome: A Cohort Study
Exhaled carbon monoxide (eCO) and fractional exhaled nitric oxide (FeNO) could reflect underlying inflammatory and oxidative stresses, which play important roles in pathogenetic pathways of metabolic syndrome ...
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Open AccessCRISPR/Cas9-mediated efficient and heritable targeted mutagenesis in tomato plants in the first and later generations
The CRISPR/Cas9 system has successfully been used in various organisms for precise targeted gene editing. Although it has been demonstrated that CRISPR/Cas9 system can induce mutation in tomato plants, the sta...
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Open AccessNaringin ameliorates bone loss induced by sciatic neurectomy and increases Semaphorin 3A expression in denervated bone
Naringin maintains bone mass in various osteoporosis models, while its effect on bone in disuse osteoporosis has not been reported. The present study explores whether naringin can prevent disuse osteoporosis i...
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Open AccessLoss of the 14-3-3σ is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway
LIM and SH3 protein 1 (LASP1) can promote colorectal cancer (CRC) progression and metastasis, but the direct evidence that elucidates the molecular mechanism remains unclear. Here, our proteomic data showed th...
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Open AccessCirculating Zinc-α2-glycoprotein levels and Insulin Resistance in Polycystic Ovary Syndrome
The aim of study was to assess the relationship between zinc-α2-glycoprotein (ZAG) and androgen excess with insulin resistance in polycystic ovary syndrome (PCOS) women. 99 PCOS women and 100 healthy controls ...
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Open AccessSelf-current induced spin-orbit torque in FeMn/Pt multilayers
Extensive efforts have been devoted to the study of spin-orbit torque in ferromagnetic metal/heavy metal bilayers and exploitation of it for magnetization switching using an in-plane current. As the spin-orbit...
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Open AccessNAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance
NAMPT has been suggested association with atherosclerosis and insulin resistance. However, the impact of NAMPT on atherosclerosis remained unknown. Therefore, the objective of this study was to use a NAMPT los...
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Open AccessPopulations of the Minor α-Conformation in AcGXGNH2 and the α-Helical Nucleation Propensities
Intrinsic backbone conformational preferences of different amino acids are important for understanding the local structure of unfolded protein chains. Recent evidence suggests α-structure is relatively minor a...
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Article
Open AccessGenome-wide DNA methylation profiles changes associated with constant heat stress in pigs as measured by bisulfite sequencing
Heat stress affects muscle development and meat quality in food animals; however, little is known regarding its regulatory mechanisms at the epigenetic level, such as via DNA methylation. In this study, we aim...
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Open AccessMetformin and gefitinib cooperate to inhibit bladder cancer growth via both AMPK and EGFR pathways joining at Akt and Erk
EGFR is a potential therapeutic target for treating bladder cancer, but has not been approved for clinical use yet. Metformin is a widely used antidiabetic drug and has demonstrated interesting anticancer effe...
