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Article
Open AccessTime-ordered dysregulated ceRNA networks reveal disease progression and diagnostic biomarkers in ischemic and dilated cardiomyopathy
Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are the two main causes of heart failure (HF). Despite similar clinical characteristics and common “HF pathways”, ICM and DCM are expected to have...
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Article
Open AccessIdentifying subpathway signatures for individualized anticancer drug response by integrating multi-omics data
Individualized drug response prediction is vital for achieving personalized treatment of cancer and moving precision medicine forward. Large-scale multi-omics profiles provide unprecedented opportunities for p...
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Article
Open AccessThe LncRNA Connectivity Map: Using LncRNA Signatures to Connect Small Molecules, LncRNAs, and Diseases
Well characterized the connections among diseases, long non-coding RNAs (lncRNAs) and drugs are important for elucidating the key roles of lncRNAs in biological mechanisms in various biological states. In this...
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Article
Open AccessLncRNAs2Pathways: Identifying the pathways influenced by a set of lncRNAs of interest based on a global network propagation method
Long non-coding RNAs (lncRNAs) have been demonstrated to play essential roles in diverse cellular processes and biological functions. Exploring the functions associated with lncRNAs may help provide insight in...
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Article
Open AccessDisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs
The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we in...
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Article
Open AccessGlobal Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network
The identification of disease-related metabolites is important for a better understanding of metabolite pathological processes in order to improve human medicine. Metabolites, which are the terminal products o...
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Article
Open AccessIdentification and validation of potential prognostic lncRNA biomarkers for predicting survival in patients with multiple myeloma
Dysregulated long non-coding RNAs (lncRNAs) have been found to have oncogenic and/or tumor suppressive roles in the development and progression of cancer, implying their potentials as novel independent biomark...
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Article
Open AccessESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis
Pathway analyses are playing an increasingly important role in understanding biological mechanism, cellular function and disease states. Current pathway-identification methods generally focus on only the chang...
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Article
Open AccessA potential signature of eight long non-coding RNAs predicts survival in patients with non-small cell lung cancer
Accumulated evidence suggests that dysregulated expression of long non-coding RNAs (lncRNAs) may play a critical role in tumorigenesis and prognosis of cancer, indicating the potential utility of lncRNAs as ca...
