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Article
Epithelioid leiomyosarcoma of broad ligament harboring PGR-NR4A3 and UBR5-PGR gene fusions: a unique case report
A novel molecular subset of epithelioid leiomyosarcomas with rhabdoid features harboring PGR gene rearrangements has recently been documented. Herein, we present a unique case of PGR-rearranged smooth muscle tumo...
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Article
Germline and tumor BRCA1/2 pathogenic variants in Chinese triple-negative breast carcinomas
BRCA1/2 screening for all triple-negative breast cancer (TNBC) patients younger than 60 years may still be an economic burden in China. Further evidences that include incidence and outcome of BRCA1/2 pathogenic v...
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Article
Open AccessImpaired AGO2/miR-185-3p/NRP1 axis promotes colorectal cancer metastasis
Increasing evidence suggests that global downregulation of miRNA expression is a hallmark of human cancer, potentially due to defects in the miRNA processing machinery. In this study, we found that the protein...
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Article
Open AccessRecurrent uterine tumors resembling ovarian sex-cord tumors with the growth regulation by estrogen in breast cancer 1-nuclear receptor coactivator 2 fusion gene: a case report and literature review
Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare mesenchymal neoplasms predominantly arising in perimenopausal and postmenopausal women. UTROSCTs with growth regulation by estrogen in brea...
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Article
Open AccessPopulation-based study of effectiveness of neoadjuvant radiotherapy on survival in US rectal cancer patients according to age
Recent cancer researches pay more attention to younger patients due to the variable treatment response among different age groups. Here we investigated the effectiveness of neoadjuvant radiation on the surviva...
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Article
Open AccessGlobal Prioritizing Disease Candidate lncRNAs via a Multi-level Composite Network
LncRNAs play pivotal roles in many important biological processes, but research on the functions of lncRNAs in human disease is still in its infancy. Therefore, it is urgent to prioritize lncRNAs that are pote...
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Article
Open AccessGlobal Prioritization of Disease Candidate Metabolites Based on a Multi-omics Composite Network
The identification of disease-related metabolites is important for a better understanding of metabolite pathological processes in order to improve human medicine. Metabolites, which are the terminal products o...
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Article
Open AccessNetwork based analyses of gene expression profile of LCN2 overexpression in esophageal squamous cell carcinoma
LCN2 (lipocalin 2) is a member of the lipocalin family of proteins that transport small, hydrophobic ligands. LCN2 is elevated in various cancers including esophageal squamous cell carcinoma (ESCC). In this study...
