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Open AccessThe Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions
Salmonella Typhi, the causative agent of typhoid fever, is a monophyletic, human-restricted bacterium that exhibits limited phenotypic variation. S. Typhi from Indonesia are a notable exception, with circulating ...
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IFITM3 restricts the morbidity and mortality associated with influenza
Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic ca...
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Article
Open AccessProbing local innate immune responses after mucosal immunisation
Intranasal immunisation is potentially a very effective route for inducing both mucosal and systemic immunity to an infectious agent.
