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Article
Open AccessTransplanting human infant gut microbiome species into Galleria mellonella
Study of the human infant gut microbiome requires the use of surrogate mammalian species such as mice. We sought to investigate the usefulness of the greater wax moth larva, Galleria mellonella, as an alternative...
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Article
Open AccessParticular genomic and virulence traits associated with preterm infant-derived toxigenic Clostridium perfringens strains
Clostridium perfringens is an anaerobic toxin-producing bacterium associated with intestinal diseases, particularly in neonatal humans and animals. Infant gut microbiome studies have recently indicated a link bet...
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Article
Open AccessClinical NEC prevention practices drive different microbiome profiles and functional responses in the preterm intestine
Preterm infants with very low birthweight are at serious risk for necrotizing enterocolitis. To functionally analyse the principles of three successful preventive NEC regimens, we characterize fecal samples of...
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Article
Questioning the fetal microbiome illustrates pitfalls of low-biomass microbial studies
Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and placenta) are stably colonized by microbial communities in a healthy pregnancy remains a subject of debate. Here we evaluat...
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Article
Open AccessTumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients
Perturbations in the gut microbiome have been associated with colorectal cancer (CRC), with the colonic overabundance of Fusobacterium nucleatum shown as the most consistent marker. Despite its significance in th...
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Article
Open AccessMaternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice
The gut microbiota plays a central role in regulating host metabolism. While substantial progress has been made in discerning how the microbiota influences host functions post birth and beyond, little is known...
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Article
Open AccessA systems genomics approach to uncover patient-specific pathogenic pathways and proteins in ulcerative colitis
We describe a precision medicine workflow, the integrated single nucleotide polymorphism network platform (iSNP), designed to determine the mechanisms by which SNPs affect cellular regulatory networks, and how...
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Article
Open AccessPRObiotics and SYNbiotics to improve gut health and growth in infants in western Kenya (PROSYNK Trial): study protocol for a 4-arm, open-label, randomised, controlled trial
Malnutrition amongst under-fives remains common in resource-poor countries and is resistant to current interventions. New opportunities have emerged to target “environmental enteric dysfunction” (EED) that ref...
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Article
Open AccessThe Pregnancy and EARly Life study (PEARL) - a longitudinal study to understand how gut microbes contribute to maintaining health during pregnancy and early life
The early life period represents the first step in establishing a beneficial microbial ecosystem, which in turn affects both short and longer-term health. Changes during pregnancy influence the neonatal microb...
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Article
Bacterial strains augment cancer therapeutics
Bifidobacterium bifidum is enriched in the gut microbiome of patients who respond to cancer treatment, but only selected strains of commercial B. bifidum reduced tumour burden synergistically with therapy in a mo...
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Article
Open AccessA rather dry subject; investigating the study of arid-associated microbial communities
Almost one third of Earth’s land surface is arid, with deserts alone covering more than 46 million square kilometres. Nearly 2.1 billion people inhabit deserts or drylands and these regions are also home to a ...
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Article
Open AccessRapid MinION profiling of preterm microbiota and antimicrobial-resistant pathogens
The MinION sequencing platform offers near real-time analysis of DNA sequence; this makes the tool attractive for deployment in fieldwork or clinical settings. We used the MinION platform coupled to the NanoOK...
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Article
Open AccessSetting the agenda for social science research on the human microbiome
The human microbiome is an important emergent area of cross, multi and transdisciplinary study. The complexity of this topic leads to conflicting narratives and regulatory challenges. It raises questions about...
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Article
Open AccessGenomic analysis on broiler-associated Clostridium perfringens strains and exploratory caecal microbiome investigation reveals key factors linked to poultry necrotic enteritis
Clostridium perfringens is a key pathogen in poultry-associated necrotic enteritis (NE). To date there are limited Whole Genome Sequencing based studies describing broiler-associated C. perfringens in healthy and...
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Article
Open AccessAntibiotic use and the risk of rheumatoid arthritis: a population-based case-control study
Antibiotic-induced disturbances of the human microbiota have been implicated in the development of chronic autoimmune conditions. This study aimed to assess whether antibiotic use is associated with the onset ...
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Article
Open AccessStreaming histogram sketching for rapid microbiome analytics
The growth in publically available microbiome data in recent years has yielded an invaluable resource for genomic research, allowing for the design of new studies, augmentation of novel datasets and reanalysis...
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Article
Open AccessOptimisation of 16S rRNA gut microbiota profiling of extremely low birth weight infants
Infants born prematurely, particularly extremely low birth weight infants (ELBW) have altered gut microbial communities. Factors such as maternal health, gut immaturity, delivery mode, and antibiotic treatment...
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Article
The microbiome beyond the horizon of ecological and evolutionary theory
The ecological and evolutionary study of community formation, diversity, and stability is rooted in general theory and reinforced by decades of system-specific empirical work. Deploying these ideas to study th...
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Live Vaccines and Their Role in Modern Vaccinology
Since the invention of vaccination by Jenner live vaccines have been key components of immunization programs. However, in the modern era the justification for the role of live vaccines is worth re-evaluating. ...
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Article
Induction and Activation of Adaptive Immune Populations During Acute and Chronic Phases of a Murine Model of Experimental Colitis
Dextran sodium sulphate (DSS) is commonly used to induce intestinal inflammation in rodents. Despite its continuing importance as a model system for examining IBD pathogenesis, the mucosal and systemic immune ...
