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Article
A novel substrate for testosterone: biodegradable and biocompatible oil gel
The androgen testosterone is less expensive than bone morphogenetic proteins and has been shown to effectively repair bone fractures. However, testosterone is lipophilic and insoluble in water, making it diffi...
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Article
Cell effects on the formation of collagen triple helix fibers inside collagen gels or on cell surfaces
Collagen molecules are widely used in the field of tissue engineering, especially as cell culture hydrogels. However, the cellular effects on collagen fiber formation inside collagen gels have not been reporte...
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Reference Work Entry In depth
Template Polymerization (Molecular Templating)
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Article
Synthesis and preparation of nanoparticles composed of amphiphilic poly(γ-glutamic acid) with different hydrophobic side chains and their potential of membrane disruptive activity
In the development of nanoparticle-based vaccine adjuvants, the interaction between nanoparticles (NPs) and the cells is a key factor. To control them, we focused on the relationship between the hydrophobicity...
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Article
Control of extracellular microenvironments using polymer/protein nanofilms for the development of three-dimensional human tissue chips
Cell functions, such as adhesion, migration, proliferation, differentiation, organization, protein expression and death, are dynamically regulated at the surface of cell membranes by the interaction between a ...
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Article
Preparation of microparticles composed of amphiphilic poly(γ-glutamic acid) through hydrophobic interactions
A novel amphiphilic graft copolymer composed of poly(γ-glutamic acid) (γ-PGA) as a hydrophilic backbone and dodecylamine (DOA) as a hydrophobic side chain (γ-PGA-DOA) was successfully synthesized by employing ...
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Article
Open AccessHTLV-1 Tax peptide-carrying polyion complex nanoparticles induce potent cellular immunity in mice
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Living Reference Work Entry In depth
Template Polymerization (Molecular Templating)
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Article
Open AccessSynergistic effects of agonistic costimulatory antibodies adsorbed to amphiphilic poly(γ-glutamic acid) nanoparticles
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Article
Synthesis of a thermosensitive polycation by random copolymerization of N-vinylformamide and N-vinylbutyramide
The novel thermoresponsive polycations poly(N-vinylbutyramide-co-vinylamide) (poly(NVBA-co-VAm)), with different mole ratios of poly(VAm) (PVAm):poly(NVBA) (PNVBA), were synthesized as a biomaterial by free radic...
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Article
A study on template effects using irregular porous isotactic poly(methyl methacrylate) films constructed with syndiotactic rich poly(methacrylic acid) and isotactic poly(methyl methacrylate)
To investigate the stereocomplex formation efficiency with various syndiotactic-poly(methacrylic acids) (st-PMAAs) after the extraction of the syndiotactic-rich PMAA from stereocomplex film, the low syndiotactici...
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Article
Preparation and characterization of nanoparticles formed through stereocomplexation between enantiomeric poly(γ-glutamic acid)-graft-poly(lactide) copolymers
Novel amphiphilic graft copolymers composed of poly(γ-glutamic acid) (γ-PGA) as a hydrophilic backbone and enantiomeric poly(lactide) (PLA) as hydrophobic side chains were successfully synthesized by using 1-e...
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Article
The systematic study of the microstructure of crosslinked copolymers from siloxane macromonomers and methacrylates by changes in composition and components
Copolymerization of polydimethylsiloxane (PDMS) macromer having two molecular weight (Mn), two types of methacrylate and crosslinker was conducted. The crosslinked copolymer was analyzed with 13C solid-state NMR ...
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Chapter
Biodegradable Nanoparticles as Vaccine Adjuvants and Delivery Systems: Regulation of Immune Responses by Nanoparticle-Based Vaccine
Polymeric nano- and microparticles have recently been shown to possess significant potential as drug delivery systems. In particular, the use of biodegradable polymeric nanoparticles with entrapped antigens su...
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Article
Polyelectrolyte multilayers-modified membrane filter for rapid immunoassay: protein condensation by centrifugal permeation
We demonstrated that positive polyelectrolyte multilayers (PEMs) have great potential for conventional enzyme-linked immunosorbent assay (ELISA) systems because of the induction protein enrichment on their sur...
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Article
EphA2-derived peptide vaccine with amphiphilic poly(γ-glutamic acid) nanoparticles elicits an anti-tumor effect against mouse liver tumor
The prognosis of liver cancer remains poor, but recent advances in nanotechnology offer promising possibilities for cancer treatment. Novel adjuvant, amphiphilic nanoparticles (NPs) composed of l-phenylalanine (P...
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Article
Morphological changes of isotactic poly(methyl methacrylate) thin films via self-organization and stereocomplex formation
Morphological changes of macromolecularly porous thin films during isotactic (it) poly(methyl methacrylate) (PMMA) crystallization and the subsequent syndiotactic (st) poly(methacrylic acid) (PMAA) incorporation ...
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Chapter
Pharmaceutical and Medical Applications of Poly-Gamma-Glutamic Acid
Poly(amino acid)s have received considerable attention for biomedical applications. Poly(γ-glutamic acid) (γ-PGA), a natural polymer, is synthesized by several gram-positive bacteria. γ-PGA is anionic, water s...
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Article
Heterofunctional Interfaces Achieve Dual Protein Adsorption on Polyelectrolyte Multilayers
Two types of polyelectrolyte multilayers were formed on both sides of a substrate by integrating an alternate adsorption process with an alternate drop-coating process. We used poly(diallyldimethylammonium chl...
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Article
Alternate drop coating for forming dual biointerfaces composed of polyelectrolyte multilayers
Two types of polyelectrolyte multilayers were formed on both sides of a quartz crystal microbalance (QCM) substrate by a novel alternate drop coating process. In this study, poly(diallyldimethylammonium chlori...
