28 Result(s)
within
Man-**g Jiang
Cancer Research
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Article
Open AccessThe prognostic value of serum C-reactive protein-bound serum amyloid A in early-stage lung cancer
Elevated levels of serum C-reactive protein (CRP) have been reported to have prognostic significance in lung cancer patients. This study aimed to further identify CRP-bound components as prognostic markers for...
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Cancer Stem Cells in Resistance to Cytotoxic Drugs: Implications in Chemotherapy
The efficacy of cytotoxic chemotherapy is limited by drug resistance presented by some cancer cells. Cancer stem cells (CSCs) are a sub-population of tumor cells that can initiate tumor formation. If chemother...
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Article
Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability
Aneuploidy and chromosomal instability are major characteristics of human cancer. These abnormalities can result from defects in the spindle assembly checkpoint (SAC), which is a surveillance mechanism for acc...
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Article
Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer
Downregulation of estrogen receptor-α (ER-α) in breast tumors can mediate resistance to ER-α–targeted therapies such as tamoxifen. This report sheds light on a therapy resistance–conferring adaptation by ident...
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Article
Activation of cloned BKCa channels in nitric oxide-induced apoptosis of HEK293 cells
The large conductance Ca2+-activated K+ (BKCa) channels are highly expressed in vascular smooth muscle cells (VSMCs) and play an essential role in the regulation of various physiological functions. Besides its el...
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Article
The genome of the cucumber, Cucumis sativus L.
Jun Wang and colleagues report the genome sequence of the cucumber. The cucumber genome is the seventh plant genome sequence to be reported and was assembled with a combination of traditional Sanger and next-g...
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Article
Coexpression and characterization of the human large-conductance Ca2+-activated K+ channel α + β1 subunits in HEK293 cells
Large-conductance Ca2+-activated K+ channel is formed by a tetramer of the pore-forming α-subunit and distinct accessory β-subunits (β1–β4) which contribute to BKCa channel molecular diversity. Accumulative evid...
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Article
Open AccessChanges in microRNA expression profiles in HIV-1-transfected human cells
MicroRNAs (miRNAs) are small RNAs of 18–25 nucleotides (nt) in length that play important roles in regulating a variety of biological processes. Recent studies suggest that cellular miRNAs may serve to control...
