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Chapter
Transcriptomic Analysis of CTCs
Circulating tumor cells (CTCs), the “seeds” of fatal metastasis, intravasate into the bloodstream throughout the early stages of cancer, promoting the generation of micrometastatic reservoirs, some of which ul...
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Article
Open AccessMolecular characterization of breast cancer CTCs associated with brain metastasis
The enumeration of EpCAM-positive circulating tumor cells (CTCs) has allowed estimation of overall metastatic burden in breast cancer patients. However, a thorough understanding of CTCs associated with breast ...
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Chapter
Cancer Stem Cells in Resistance to Cytotoxic Drugs: Implications in Chemotherapy
The efficacy of cytotoxic chemotherapy is limited by drug resistance presented by some cancer cells. Cancer stem cells (CSCs) are a sub-population of tumor cells that can initiate tumor formation. If chemother...