75 Result(s)

Article

B7-DC (PD-L2) costimulation of CD4⁺ T-helper 1 response via RGMb

The role of B7-DC in T-cell responses remains controversial because both coinhibitory and costimulatory functions have been reported in various experimental systems in vitro and in vivo. In addition to interactin...

**nxin Nie, Wenni Chen, Ying Zhu, Baozhu Huang… in Cellular & Molecular Immunology (2018)

Article

A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma

Programmed death one homolog (PD-1H) is a cell surface molecule of the B7/CD28 immune modulatory gene family. Although PD-1H has been shown to function as a coinhibitory receptor on T cells to limit naive T-ce...

Huafeng Liu, **n Li, Li Hu, Min Zhu, Bailin He… in Cellular & Molecular Immunology (2018)

Article

Functional circuit architecture underlying parental behaviour

Parenting is essential for the survival and wellbeing of mammalian offspring. However, we lack a circuit-level understanding of how distinct components of this behaviour are coordinated. Here we investigate ho...

Johannes Kohl, Benedicte M. Babayan, Nimrod D. Rubinstein, Anita E. Autry… in Nature (2018)

Article

Teneurin-3 controls topographic circuit assembly in the hippocampus

Brain functions rely on specific patterns of connectivity. Teneurins are evolutionarily conserved transmembrane proteins that instruct synaptic partner matching in Drosophila and are required for vertebrate visua...

Dominic S. Berns, Laura A. DeNardo, Daniel T. Pederick, Liqun Luo in Nature (2018)

Article

Rabies screen reveals GPe control of cocaine-triggered plasticity

Identification of neural circuit changes that contribute to behavioural plasticity has routinely been conducted on candidate circuits that were preselected on the basis of previous results. Here we present an ...

Kevin T. Beier, Christina K. Kim, Paul Hoerbelt, Lin Wai Hung, Boris D. Heifets… in Nature (2017)

Article

A bitter–sweet symphony

Information about taste sensations, such as bitter or sweet, is relayed from the mouse tongue to the brain through taste-specific pathways. It emerges that semaphorin proteins guide the wiring of these pathways.

Jiefu Li, Liqun Luo in Nature (2017)

Article

Identification of preoptic sleep neurons using retrograde labelling and gene profiling

Identification of sleep-active and sleep-promoting neurons in the preoptic area of the hypothalamus using neural projection tracing tools to target this population among a group of intermingled neurons, all wi...

Shinjae Chung, Franz Weber, Peng Zhong, Chan Lek Tan, Thuc Nghi Nguyen… in Nature (2017)

Article

Cerebellar granule cells encode the expectation of reward

A sizable fraction of granule cells convey information about the expectation of reward, with different populations responding to reward delivery, anticipation and omission, with some responses evolving over ti...

Mark J. Wagner, Tony Hyun Kim, Joan Savall, Mark J. Schnitzer, Liqun Luo in Nature (2017)

Article

Cas9-triggered chain ablation of cas9 as a gene drive brake

Bing Wu, Liqun Luo, **ao**g J Gao in Nature Biotechnology (2016)

Article

Connectivity of mouse somatosensory and prefrontal cortex examined with trans-synaptic tracing

The authors used trans-synaptic tracing to examine and compare circuit anatomy in mouse barrel and medial prefrontal cortex, revealing novel organizational features and contrasts between the two areas. Notably...

Laura A DeNardo, Dominic S Berns, Katherine DeLoach, Liqun Luo in Nature Neuroscience (2015)

Article

Basal forebrain circuit for sleep-wake control

The basal forebrain (BF) is important for sleep-wake control. In this study, the authors performed cell type–specific recording and manipulation of four genetically defined BF cell types in freely moving mice ...

Min Xu, Shinjae Chung, Siyu Zhang, Peng Zhong, Chenyan Ma… in Nature Neuroscience (2015)

Article

Control of REM sleep by ventral medulla GABAergic neurons

Activation of GABAergic neurons in the ventral medulla can reliably induce REM sleep and prolong the duration of REM episodes in mice.

Franz Weber, Shinjae Chung, Kevin T. Beier, Min Xu, Liqun Luo, Yang Dan in Nature (2015)

Article

Viral-genetic tracing of the input–output organization of a central noradrenaline circuit

To better understand the relationship between input and output connectivity for neurons of interest in specific brain regions, a viral-genetic tracing approach is used to identify input based on a combination ...

Lindsay A. Schwarz, Kazunari Miyamichi, **ao**g J. Gao, Kevin T. Beier… in Nature (2015)

Article

A transcriptional reporter of intracellular Ca²⁺ in Drosophila

The authors developed a transcriptional reporter of intracellular Ca²⁺ and used it to monitor activity in Drosophila sensory and neuromodulatory neurons. They demonstrate that this tool can be used to manipulate ...

**ao**g J Gao, Olena Riabinina, Jiefu Li, Christopher J Potter… in Nature Neuroscience (2015)

Article

Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain

The brain has a limited capacity to self-protect against protein aggregate-associated pathology, and mounting evidence supports a role for phagocytic glia in this process. We have established a Drosophila model t...

Margaret M. P. Pearce, Ellen J. Spartz, Weizhe Hong, Liqun Luo… in Nature Communications (2015)

Article

Improved and expanded Q-system reagents for genetic manipulations

Binary expression systems such as the Gal4-UAS or Q-systems are useful tools for genetic manipulation in Drosophila. Here, improved reagents for the Q-system are described.

Olena Riabinina, David Luginbuhl, Elizabeth Marr, Sha Liu, Mark N Wu… in Nature Methods (2015)