48 Result(s)
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Article
Inositol-Triphosphate 3-Kinase C and DNA Methylation Involvement in NLRP3 Inflammasome Activation in Kawasaki Disease
To evaluate ITPKC and NLRP3 expression in children with Kawasaki disease (KD) and investigate the relationship between serum pro-inflammatory cytokines triggered by NLRP3 and inflammatory indices. Simultaneous...
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Secondary genomic findings in the 2020 China Neonatal Genomes Project participants
During next generation sequencing (NGS) data interpretation in critically ill newborns, there is a potential for recognizing and reporting secondary findings (SFs). Early awareness of SFs may provide clues for...
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Open AccessNon-parental caregivers, low maternal education, gastrointestinal problems and high blood lead level: predictors related to the severity of autism spectrum disorder in Northeast China
The prevalence of autism spectrum disorder (ASD) has increased rapidly in recent years. Environmental factors may play an important role in the pathogenesis of ASD. These factors may include socioeconomic fact...
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Article
Evaluation of a new frequency–volume chart for children with primary monosymptomatic nocturnal enuresis: a prospective, comparative study
To improve compliance with voiding diaries in children with primary monosymptomatic nocturnal enuresis (PMNE), a new modified 3-day weekend frequency–volume chart (FVC) was designed, and the compliance and val...
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Open AccessEarly initial video-electro-encephalography combined with variant location predict prognosis of KCNQ2-related disorder
The clinical features of KCNQ2-related disorders range from benign familial neonatal seizures 1 to early infantile epileptic encephalopathy 7. The genotype-phenotypic association is difficult to establish.
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Expert consensus on COVID-19 vaccination in children
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Clinical and molecular characteristics of Staphylococcus aureus isolated from Chinese children: association among the agr groups and genotypes, virulence genes and disease types
This study was aimed to investigate the clinical and molecular epidemiology of Staphylococcus aureus (S. aureus) isolated from Chinese children and determine the possible relationship among the accessory gene reg...
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Clinical features and risk factors in patients with asthma complicated with obstructive sleep apnea-hypopnea syndrome: a hospital-based study
The current study was conducted to explore the clinical features and risk factors of patients with asthma complicated by obstructive sleep apnea-hypopnea syndrome (OSAHS).
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Surrogate markers and predictors of endogenous insulin secretion in children and adolescents with type 1 diabetes
No studies have examined endogenous insulin secretion in pediatric patients with type 1 diabetes in China using the gold-standard mixed-meal tolerance test. Because the latter is labor-intensive, we examined s...
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Open AccessClinical and imaging features of pediatric COVID-19
Pediatric COVID-19 is relatively mild and may vary from that in adults. This study was to investigate the epidemic, clinical, and imaging features of pediatric COVID-19 pneumonia for early diagnosis and treatm...
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Article
Best practice for infection prevention in pediatric respiratory clinics during the COVID-19 epidemic
During the COVID-19 epidemic, it is important for ensuring infection prevention and control in the pediatric respiratory clinics. Herein, we introduced the practice of infection prevention and control in pedia...
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Article
Updated diagnosis, treatment and prevention of COVID-19 in children: experts’ consensus statement (condensed version of the second edition)
In the early February, 2020, we called up an experts’ committee with more than 30 Chinese experts from 11 national medical academic organizations to formulate the first edition of consensus statement on diagno...
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Open AccessShort-term outcomes of extremely preterm infants at discharge: a multicenter study from Guangdong province during 2008–2017
An increasing number of extremely preterm (EP) infants have survived worldwide. However, few data have been reported from China. This study was designed to investigate the short-term outcomes of EP infants at ...
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Article
Open AccessSevere clinical manifestation of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency associated with two novel mutations: a case report
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHS) deficiency is an autosomal recessive inborn error of metabolism, which will give rise to failure of ketogenesis in liver during illness or fasting. I...
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Article
A negative regulator of synaptic development: MDGA and its links to neurodevelopmental disorders
Formation of protein complexes across synapses is a critical process in neurodevelopment, having direct implications on brain function and animal behavior. Here, we present the understanding, importance, and p...
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Open AccessEstablishment of an efficient reverse genetic system of Mumps virus S79 from cloned DNA
Mumps is a common type of respiratory infectious disease caused by mumps virus (MuV), and can be effectively prevented by vaccination. In this study, a reverse genetic system of MuV that can facilitate the rat...
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Article
Attenuated MuV-S79 as vector stably expressing foreign gene
To describe mumps virus (MuV) used as a vector to express enhanced green fluorescent protein (EGFP) or red fluorescent protein (RFP) genes.
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Article
Chinese clinical practice guidelines for acute infectious diarrhea in children
The guidelines addressed the evidence-based indications for the management of children with acute infectious diarrhea in Chinese pediatric population.
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Article
Antibiotic usage in Chinese children: a point prevalence survey
Children as a population have high antimicrobial prescribing rates which may lead to high resistance of bacteria according to data from some single-center surveys of antibiotic prescribing rates in China. The ...
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Article
Plasma gelsolin level predicts acute kidney injury after cardiopulmonary bypass in infants and young children
Acute kidney injury (AKI) after cardiopulmonary bypass (CPB) is a common complication especially in pediatric population. Plasma gelsolin (pGSN) is an anti-inflammatory factor through binding with actin and pr...
